Journal article
An Evaluation of the Clinical Therapeutic Effect of Lixisenatide in Type 2 Diabetes Patients: A Systematic Literature Review
Current diabetes reviews, Vol.14(4), pp.363-375
01/01/2018
DOI: 10.2174/1573399813666170724113240
PMID: 28738763
Abstract
Background: With cardiovascular disease accounting for approximately 50% of deaths in patients diagnosed with type 2 diabetes, it is pertinent to initiate anti-diabetic medications with cardiovascular benefits. This systematic clinical review critically examines the clinical therapeutic effect of lixisenatide.
Methods: Data were gathered from articles indexed in PubMed, Google Scholar and Medline from 2010 - 2017, with the following search terms, "lixisenatide" and "GLP-1 receptor agonist". Studies written in the English language were included.
Results: Thirteen clinical studies which evaluated the efficacy of lixisenatide were analyzed. Results from these studies showed that lixisenatide is an effective monotherapy in the reduction of glycated hemoglobin (A(1)C), Postprandial Glucose (PPG) and Fasting Blood Glucose (FPG). As an add-on therapy to metformin or sulfonylureas and insulin, it was found to be clinically effective compared to placebo. In all reviewed trials, there were higher proportions of patients who achieved A1C < 7% or < 6.5% compared to placebo without a corresponding increase in weight. Finally, the use of lixisenatide was not associated with an increased risk of cardiovascular events. The most common adverse events in all lixisenatide groups were nausea, vomiting, and diarrhea.
Conclusion: Lixisenatide appears to be safe and effective therapy for the management of type 2 diabetes mellitus. It is not associated with either the risk of cardiovascular events or symptomatic hypoglycemia. Finally, lixisenatide may be best used as an adjunct therapy for patients who are inadequately controlled with other diabetic medications, or select group of patients at risk of insulin induced obesity, hypertension or heart failure.
Details
- Title: Subtitle
- An Evaluation of the Clinical Therapeutic Effect of Lixisenatide in Type 2 Diabetes Patients: A Systematic Literature Review
- Creators
- Arinze Nkemdirim Okere - Florida Agricultural and Mechanical UniversityJanele Montesdeoca - Florida Agricultural and Mechanical UniversityApril Glasper - Florida Agricultural and Mechanical UniversityVakaramoko Diaby - Florida Agricultural and Mechanical University
- Resource Type
- Journal article
- Publication Details
- Current diabetes reviews, Vol.14(4), pp.363-375
- Publisher
- Bentham Science Publ Ltd
- DOI
- 10.2174/1573399813666170724113240
- PMID
- 28738763
- ISSN
- 1573-3998
- eISSN
- 1875-6417
- Number of pages
- 13
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Pharmacy Practice and Science; Internal Medicine
- Record Identifier
- 9984845212602771
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