Journal article
An Extranodal Nasal Natural Killer/T-Cell Lymphoma With Isochromosome 7q10 as the Sole Cytogenetic Aberration Was Initially Diagnosed Via Bone Marrow Biopsy
Archives of pathology & laboratory medicine (1976), Vol.131(11), pp.1709-1714
11/01/2007
DOI: 10.5858/2007-131-1709-AENNTL
PMID: 17979491
Abstract
Abstract We report a 58-year-old man who presented with fever, pancytopenia, hepatosplenomegaly, and “sinusitis” of his right nostril. Flow cytometric analysis of his bone marrow aspirate revealed a population of cells that were CD56+ (bright), CD2+ (dim), and CD7+ (slight brightly) but negative for CD3, CD4, CD5, CD8, CD11b, CD16, CD57, and T-cell receptors, consistent with aberrant natural killer cells. Bone marrow biopsy showed an atypical lymphoid infiltrate expressing CD56 as well as Epstein-Barr virus– encoded RNA and histiocytic hyperplasia with hemophagocytosis. Subsequent biopsy of his right nasal vestibule demonstrated an atypical lymphoid infiltrate, which was cytoplasmic CD3+, CD56+, and Epstein-Barr virus–encoded RNA positive, consistent with an extranodal nasal natural killer cell lymphoma. Conventional cytogenetic studies of the bone marrow revealed isochromosome 7q10 [i(7)(q10)] as the sole chromosomal aberration. To our knowledge, this is the first report demonstrating i(7)(q10) as a primary cytogenetic abnormality in an extranodal nasal natural killer cell lymphoma.
Details
- Title: Subtitle
- An Extranodal Nasal Natural Killer/T-Cell Lymphoma With Isochromosome 7q10 as the Sole Cytogenetic Aberration Was Initially Diagnosed Via Bone Marrow Biopsy
- Creators
- Huan-You Wang - From the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. Dr Xu is now with the Genoptix Medical Laboratory, Carlsbad, CalifKathleen S Wilson - From the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. Dr Xu is now with the Genoptix Medical Laboratory, Carlsbad, CalifRobert W McKenna - From the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. Dr Xu is now with the Genoptix Medical Laboratory, Carlsbad, CalifYin Xu - From the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. Dr Xu is now with the Genoptix Medical Laboratory, Carlsbad, CalifNitin Karandikar - From the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. Dr Xu is now with the Genoptix Medical Laboratory, Carlsbad, Calif
- Resource Type
- Journal article
- Publication Details
- Archives of pathology & laboratory medicine (1976), Vol.131(11), pp.1709-1714
- DOI
- 10.5858/2007-131-1709-AENNTL
- PMID
- 17979491
- ISSN
- 0003-9985
- eISSN
- 1543-2165
- Language
- English
- Date published
- 11/01/2007
- Academic Unit
- Pathology
- Record Identifier
- 9984047894502771
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