Journal article
An Integrative Tinnitus Model Based on Sensory Precision
Trends in neurosciences (Regular ed.), Vol.39(12), pp.799-812
12/01/2016
DOI: 10.1016/j.tins.2016.10.004
PMCID: PMC5152595
PMID: 27871729
Abstract
Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are incompletely understood. Current theories proposing pathophysiology from the ear to the cortex cannot individually - or collectively - explain the range of experimental evidence available. We propose a new framework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway constitutes a 'tinnitus precursor' which is normally ignored as imprecise evidence against the prevailing percept of 'silence'. Extant models feature as contributory mechanisms acting to increase either the intensity of the precursor or its precision. If precision (i.e., postsynaptic gain) rises sufficiently then tinnitus is perceived. Perpetuation arises through focused attention, which further increases the precision of the precursor, and resetting of the default prediction to expect tinnitus.
Details
- Title: Subtitle
- An Integrative Tinnitus Model Based on Sensory Precision
- Creators
- William Sedley - Newcastle UniversityKarl J. Friston - Wellcome Centre for Human NeuroimagingPhillip E. Gander - University of IowaSukhbinder Kumar - Wellcome Centre for Human NeuroimagingTimothy D. Griffiths - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.39(12), pp.799-812
- DOI
- 10.1016/j.tins.2016.10.004
- PMID
- 27871729
- PMCID
- PMC5152595
- NLM abbreviation
- Trends Neurosci
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- Wellcome Trust; European Commission Academy of Medical Sciences (UK) MR/J011207/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Medical Research Council (UK); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) SGL015\\1024 / Academy of Medical Sciences (AMS) MR/J011207/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission
- Language
- English
- Date published
- 12/01/2016
- Academic Unit
- Radiology; Psychological and Brain Sciences; Neurosurgery; Otolaryngology
- Record Identifier
- 9984303895902771
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