An Iron-Binding Exochelin Prevents Restenosis Due to Coronary Artery Balloon Injury in a Porcine Model

Eli A. Rosenthal; Teri J. Bohlmeyer; Eric Monnet; Catriona MacPhail; Alastair D. Robertson; Marcus A. Horwitz; J.E.B. Burchenal; Lawrence D. Horwitz

doi:10.1161/hc4301.097194

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An Iron-Binding Exochelin Prevents Restenosis Due to Coronary Artery Balloon Injury in a Porcine Model

Journal article

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An Iron-Binding Exochelin Prevents Restenosis Due to Coronary Artery Balloon Injury in a Porcine Model

Eli A. Rosenthal, Teri J. Bohlmeyer, Eric Monnet, Catriona MacPhail, Alastair D. Robertson, Marcus A. Horwitz, J.E.B. Burchenal and Lawrence D. Horwitz

Circulation (New York, N.Y.), Vol.104(18), pp.2222-2227

10/30/2001

DOI: 10.1161/hc4301.097194

PMID: 11684635

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Abstract

Background Vascular smooth muscle cell (VSMC) proliferation is a critical factor in the neointima formation that causes restenosis after coronary angioplasty (PTCA). Desferri-exochelin 772SM (D-EXO), a highly diffusible, lipophilic iron chelator secreted by Mycobacterium tuberculosis , inhibits proliferation of VSMCs in culture. We hypothesized that treatment with D-EXO would inhibit neointima formation in balloon-injured vessels in vivo. Methods and Results We subjected 24 pigs to overstretch coronary artery injury with standard PTCA balloons and then administered intramural injections of either D-EXO (n=14) or vehicle (n=10) through an Infiltrator catheter. Treatments were randomized, and the investigators were blinded with regard to treatment group until data analysis was completed. One month later, we euthanized the pigs, excised the injured coronary segments, made multiple sections of each segment, and identified the site of maximal neointima formation. An injury score based on the degree of disruption of the internal or external elastic lamina or media was assigned. D-EXO reduced stenosis index (neointima area divided by the area within the internal elastic lamina), adjusted for injury score, by 47%. Neointima thickness was also reduced. Conclusions D-EXO, injected intramurally, substantially inhibited formation of neointima in a porcine vascular injury model.

Details

Title: Subtitle: An Iron-Binding Exochelin Prevents Restenosis Due to Coronary Artery Balloon Injury in a Porcine Model
Creators: Eli A. Rosenthal - University of Colorado Health
Teri J. Bohlmeyer - Colorado State University
Eric Monnet - Colorado State University
Catriona MacPhail - Colorado State University
Alastair D. Robertson - University of Colorado Health
Marcus A. Horwitz - University of California, Los Angeles
J.E.B. Burchenal - Colorado State University
Lawrence D. Horwitz - Colorado State University
Resource Type: Journal article
Publication Details: Circulation (New York, N.Y.), Vol.104(18), pp.2222-2227
DOI: 10.1161/hc4301.097194
PMID: 11684635
NLM abbreviation: Circulation
ISSN: 0009-7322
eISSN: 1524-4539
Language: English
Date published: 10/30/2001
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984656596102771

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