Journal article
An MRI study of autism: The cerebellum revisited
Neurology, Vol.49(2), pp.546-551
08/01/1997
DOI: 10.1212/WNL.49.2.546
PMID: 9270594
Abstract
We addressed the controversies surrounding the size of the neocerebellar vermis in autism and examined cerebellar size in light of recent reports of enlarged brain size in this disorder. In this study we use detailed MRI (1.5 mm) to examine the area of cerebellar lobules I through V and VI and VII and the volume of the total cerebellum in 35 autistic subjects and 36 controls. No abnormalities in the size of cerebellar lobules VI and VII in autistic individuals were detected, but the volume of the total cerebellum was significantly increased. We conclude that selective neocerebellar size abnormalities are not present in autistic individuals. Enlarged total cerebellar volume detected in this study is consistent with previous reports of regional brain enlargement in autism and also consistent with theories hypothesizing that the primary defect in autism is the result of abnormal development of a distributed neural network involving a number of regions of the brain.
Details
- Title: Subtitle
- An MRI study of autism: The cerebellum revisited
- Creators
- Joseph Piven - University of IowaKhalil Saliba - University of IowaJames Bailey - University of IowaStephan Arndt - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.49(2), pp.546-551
- DOI
- 10.1212/WNL.49.2.546
- PMID
- 9270594
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Number of pages
- 6
- Language
- English
- Date published
- 08/01/1997
- Academic Unit
- Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132074602771
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