Journal article
An Overview of Animal Models of Pain: Disease Models and Outcome Measures
The journal of pain, Vol.14(11), pp.1255-1269
11/2013
DOI: 10.1016/j.jpain.2013.06.008
PMCID: PMC3818391
PMID: 24035349
Abstract
Pain is ultimately a perceptual phenomenon. It is built from information gathered by specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and integrated into a discrete sensory experience with an emotional valence in the brain. Because of this, studying intact animals allows the multidimensional nature of pain to be examined. A number of animal models have been developed, reflecting observations that pain phenotypes are mediated by distinct mechanisms. Animal models of pain are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments. Outcome measures are designed to measure multiple parts of the pain experience, including reflexive hyperalgesia measures, sensory and affective dimensions of pain, and impact of pain on function and quality of life. In this review, we discuss the common methods used for inducing each of the pain phenotypes related to clinical pain syndromes as well as the main behavioral tests for assessing pain in each model.
Understanding animal models and outcome measures in animals will assist in translating data from basic science to the clinic.
Details
- Title: Subtitle
- An Overview of Animal Models of Pain: Disease Models and Outcome Measures
- Creators
- Nicholas S Gregory - Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa, Iowa City, IowaAmber L Harris - Department of Psychology, College of Science, University of Texas Arlington, Arlington, TexasCaleb R Robinson - Department of Anesthesia & Pain Medicine Research, The University of Texas M.D. Anderson Cancer Center, Houston, TexasPatrick M Dougherty - Department of Anesthesia & Pain Medicine Research, The University of Texas M.D. Anderson Cancer Center, Houston, TexasPerry N Fuchs - Department of Psychology, College of Science, University of Texas Arlington, Arlington, TexasKathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The journal of pain, Vol.14(11), pp.1255-1269
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpain.2013.06.008
- PMID
- 24035349
- PMCID
- PMC3818391
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Grant note
- AR061371; AR052315; AR053509; AR063381; NS046606; CA124787 / National Institutes of Health
- Language
- English
- Date published
- 11/2013
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040223402771
Metrics
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