Journal article
An Update on the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction Trial: 1-Year Safety and Angiographic Results
American journal of neuroradiology : AJNR, Vol.39(5), pp.848-851
05/2018
DOI: 10.3174/ajnr.A5599
PMID: 29599174
Abstract
The safety and efficacy of the PulseRider for the treatment of wide-neck, bifurcation aneurysms at the basilar and carotid terminus locations were studied in a prospective trial, the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction (ANSWER) trial, reporting on initial 6-month angiographic and clinical results. This report provides insight into the longer term durability and safety with 12-month data.
Aneurysms treated with the PulseRider among enrolled sites were prospectively studied. Updated 12-month data on clinical and imaging end points are included.
Thirty-four patients were enrolled (29 women, 5 men) with a mean age of 60.9 years. The mean aneurysm height ranged from 2.4 to 15.9 mm with a mean neck size of 5.2 mm (range, 2.3-11.6 mm). At 1 year, there were no device migrations or symptomatic in-stent stenoses. Raymond-Roy I occlusion was achieved in 53% of cases at the time of treatment and progressed to 61% and 67% at 6 and 12 months, respectively. Adequate occlusion (Raymond-Roy I/II) progressed from 88% at 6 months to 90% at 12 months. No recanalizations were observed. There was 1 delayed ischemic event. Good outcome (mRS 0-2) was achieved in 90% of patients.
The updated 1-year results from the ANSWER trial demonstrate aneurysm stability and an acceptable safety profile for aneurysms treated at the basilar apex and carotid terminus. Prospective data from a larger set of aneurysms treated at other locations are required to assess how treatment with PulseRider compares with alternatives for treating wide-neck bifurcation aneurysms.
Details
- Title: Subtitle
- An Update on the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction Trial: 1-Year Safety and Angiographic Results
- Creators
- A M Spiotta - From the Department of Neurosurgery (A.M.S., M.I.C., R.D.T., A.S.T.), Medical University of South Carolina, Charleston, South Carolina spiotta@musc.eduM I Chaudry - From the Department of Neurosurgery (A.M.S., M.I.C., R.D.T., A.S.T.), Medical University of South Carolina, Charleston, South CarolinaR D Turner IV - From the Department of Neurosurgery (A.M.S., M.I.C., R.D.T., A.S.T.), Medical University of South Carolina, Charleston, South CarolinaA S Turk - From the Department of Neurosurgery (A.M.S., M.I.C., R.D.T., A.S.T.), Medical University of South Carolina, Charleston, South CarolinaC P Derdeyn - Department of Radiology (C.P.D.), University of Iowa, Iowa City, IowaJ Mocco - Department of Neurosurgery (J.M.), Mount Sinai Hospital, New York, New YorkS Tateshima - Department of Radiology (S.T.), University of California, Los Angeles, Los Angeles, California
- Resource Type
- Journal article
- Publication Details
- American journal of neuroradiology : AJNR, Vol.39(5), pp.848-851
- DOI
- 10.3174/ajnr.A5599
- PMID
- 29599174
- NLM abbreviation
- AJNR Am J Neuroradiol
- ISSN
- 0195-6108
- eISSN
- 1936-959X
- Publisher
- United States
- Grant note
- name: Pulsar Vascular
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020751102771
Metrics
31 Record Views