An acoustofluidic sputum liquefier

Po-Hsun Huang; Liqiang Ren; Nitesh Nama; Sixing Li; Peng Li; Xianglan Yao; Rosemarie A Cuento; Cheng-Hsin Wei; Yuchao Chen; Yuliang Xie; Ahmad Ahsan Nawaz; Yael G Alevy; Michael J Holtzman; J. Philip McCoy; Stewart J Levine; Tony Jun Huang

doi:10.1039/C5LC00539F

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Journal article

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An acoustofluidic sputum liquefier

Po-Hsun Huang, Liqiang Ren, Nitesh Nama, Sixing Li, Peng Li, Xianglan Yao, Rosemarie A Cuento, Cheng-Hsin Wei, Yuchao Chen, Yuliang Xie, …

Lab on a chip, Vol.15(15), pp.3125-3131

2015

DOI: 10.1039/C5LC00539F

PMCID: PMC6518399

PMID: 26082346

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https://www.ncbi.nlm.nih.gov/pmc/articles/6518399View

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Abstract

We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min−1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

Details

Title: Subtitle: An acoustofluidic sputum liquefier
Creators: Po-Hsun Huang - Pennsylvania State University
Liqiang Ren - Pennsylvania State University
Nitesh Nama - Pennsylvania State University
Sixing Li - Pennsylvania State University
Peng Li - Pennsylvania State University
Xianglan Yao - National Heart Lung and Blood Institute
Rosemarie A Cuento - National Heart Lung and Blood Institute
Cheng-Hsin Wei - Pennsylvania State University
Yuchao Chen - Pennsylvania State University
Yuliang Xie - Pennsylvania State University
Ahmad Ahsan Nawaz - Pennsylvania State University
Yael G Alevy - Washington University in St. Louis
Michael J Holtzman - Washington University in St. Louis
J. Philip McCoy - National Heart Lung and Blood Institute
Stewart J Levine - National Heart Lung and Blood Institute
Tony Jun Huang - Pennsylvania State University
Resource Type: Journal article
Publication Details: Lab on a chip, Vol.15(15), pp.3125-3131
DOI: 10.1039/C5LC00539F
PMID: 26082346
PMCID: PMC6518399
NLM abbreviation: Lab Chip
ISSN: 1473-0197
eISSN: 1473-0189
Grant note: DOI: 10.13039/100000001, name: National Science Foundation, award: IIP-1346440
Language: English
Date published: 2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984197141302771

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