Journal article
An analysis of the effect of statins on the risk of Non‐Hodgkin's Lymphoma in the Women’s Health Initiative cohort
Cancer medicine (Malden, MA), Vol.7(5), pp.2121-2130
04/02/2018
DOI: 10.1002/cam4.1368
PMCID: PMC5943473
PMID: 29608241
Abstract
Statins have been shown to induce a phosphoprotein signature that modifies MYC (myelocytomatosis viral oncogene) activation and to have anti-inflammatory activity that may impact the risk of Non-Hodgkin's lymphoma (NHL). We analyzed the relationship between statins and risk of NHL using data from the Women's Health Initiative (WHI). The study population included 161,563 postmenopausal women ages 50–79 years from which 712 cases of NHL were diagnosed after 10.8 years of follow-up. Information on statin use and other risk factors was collected by self- and interviewer-administered questionnaires. Multivariable-adjusted HR and 95% CI evaluating the relationship between statin use at baseline, as well as in a time-dependent manner and risk of NHL, were computed from Cox proportional hazards analyses. A separate analysis was performed for individual NHL subtypes: diffuse large B-Cell lymphoma (DLBCL) (n = 228), follicular lymphoma (n = 169), and small lymphocytic lymphoma (n = 74). All statistical tests were two-sided. There was no significant association between use of statins at baseline and risk of NHL (HR 0.85, 95% C.I. 0.67–1.08). However, in the multivariable-adjusted time-dependent models, statin use was associated with a borderline lower risk of NHL (HR 0.81, 95% C.I. 0.66–1.00). Considering subtypes of NHL, statin use was associated with a lower risk of DLBCL (HR 0.62, 95% C.I. 0.42–0.91). This effect was driven by lipophilic statins (HR 0.62, 95% C.I. 0.40–0.96). In the WHI, statins were associated with a lower overall risk of DLBCL, particularly attributable to lipophilic statins. These results may have impact on primary or secondary prevention of NHL, particularly DLBCL.
Details
- Title: Subtitle
- An analysis of the effect of statins on the risk of Non‐Hodgkin's Lymphoma in the Women’s Health Initiative cohort
- Creators
- Pinkal Desai - Cornell UniversityRobert Wallace - University of IowaMatthew L. Anderson - Baylor College of MedicineBarbara V. Howard - Georgetown-Howard Universities Center for Clinical and Translational ScienceRoberta Ray - Fred Hutch Cancer CenterChunyuan Wu - Fred Hutch Cancer CenterMonika Safford - Cornell UniversityLisa W. Martin - George Washington UniversityNicolas Schlecht - Albert Einstein College of MedicineSimin Liu - Brown UniversityDominic Cirillo - University of IowaAllison JayJoAnn E. Manson - Brigham and Women's HospitalMichael S. Simon - The Barbara Ann Karmanos Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Cancer medicine (Malden, MA), Vol.7(5), pp.2121-2130
- DOI
- 10.1002/cam4.1368
- PMID
- 29608241
- PMCID
- PMC5943473
- NLM abbreviation
- Cancer Med
- ISSN
- 2045-7634
- eISSN
- 2045-7634
- Publisher
- John Wiley and Sons Inc
- Grant note
- National Heart, Lung, and Blood Institute N01WH22110; 24152; 32100‐2; 32105‐6; 32108‐9; 32111‐13; 32115; 32118‐32119; 32122, 42107‐26; 42129‐32; 44221 / U.S. Department of Health and Human Services NCI P30CA022453 / National Institutes of Health
- Language
- English
- Date published
- 04/02/2018
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363644902771
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