An antibody to the Drosophila period protein recognizes circadian pacemaker neurons in Aplysia and Bulla

Kathleen K Siwick; Stefan Strack; Michael Rosbash; Jeffrey C Hall; Jon W Jacklet

doi:10.1016/0896-6273(89)90114-1

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An antibody to the Drosophila period protein recognizes circadian pacemaker neurons in Aplysia and Bulla

Journal article

Peer reviewed

An antibody to the Drosophila period protein recognizes circadian pacemaker neurons in Aplysia and Bulla

Kathleen K Siwick, Stefan Strack, Michael Rosbash, Jeffrey C Hall and Jon W Jacklet

Neuron (Cambridge, Mass.), Vol.3(1), pp.51-58

1989

DOI: 10.1016/0896-6273(89)90114-1

PMID: 2695147

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Abstract

The molecular mechanisms of the pacemakers underlying circadian rhythms are not well understood. One molecule that presumably functions in the circadian clock of Drosophila is the product of the period ( per) gene, which dramatically affects biological rhythms when mutated. An antibody specific for the per protein labels putative circadian pacemaker neurons and fibers in eyes of two marine gastropods, Aplysia and Bulla. As was found for the Drosophila per protein, there is a daily rhythm in the levels of the per-like antigen in Aplysia eyes. Thus, certain molecular features of the per protein, as well as aspects of the temporal regulation of its expression, may be conserved in circadian pacemakers of widely divergent species.

Details

Title: Subtitle: An antibody to the Drosophila period protein recognizes circadian pacemaker neurons in Aplysia and Bulla
Creators: Kathleen K Siwick - Department of Biology Brandeis University Waltham, Massachusetts 02254, USA
Stefan Strack - Department of Biological Sciences Neurobiology Research Center State University of New York at Albany Albany, New York 12222, USA
Michael Rosbash - Department of Biology Brandeis University Waltham, Massachusetts 02254, USA
Jeffrey C Hall - Department of Biology Brandeis University Waltham, Massachusetts 02254, USA
Jon W Jacklet - Department of Biological Sciences Neurobiology Research Center State University of New York at Albany Albany, New York 12222, USA
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.3(1), pp.51-58
DOI: 10.1016/0896-6273(89)90114-1
PMID: 2695147
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier Inc
Language: English
Date published: 1989
Academic Unit: Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984040373002771

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