Journal article
An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes
FEMS microbiology letters, Vol.144(2), pp.151-155
1996
DOI: 10.1016/0378-1097(96)00351-5
PMID: 8900058
Abstract
An open reading frame (
pelA) specifying a homolog of pelota and DOM34, proteins required for meiotic cell division in
Drosophila melanogaster and
Saccharomyces cerevisiae, respectively, has been cloned, sequenced and identified from the archaebacterium
Sulfolobus solfataricus. The
S. solfataricus PelA protein is about 20% identical with pelota, DOM34 and the hypothetical protein R74.6 of
Caenorhabditis elegans. The presence of a pelota homolog in archaebacteria implies that the meiotic functions of the eukaryotic protein were co-opted from, or added to, other functions existing before the emergence of eukaryotes. The nuclear localization signal and negatively charged carboxy-terminus characteristic of eukaryotic pelota-like proteins are absent from the
S. solfataricus homolog, and hence may be indicative of the acquired eukaryotic function(s).
Details
- Title: Subtitle
- An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes
- Creators
- Mark A Ragan - Program in Evolutionary Biology, Canadian Institute for Advanced Research, National Research Council of Canada, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, CanadaJohn M Logsdon - Department of Biochemistry, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, CanadaChristoph W Sensen - Program in Evolutionary Biology, Canadian Institute for Advanced Research, National Research Council of Canada, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, CanadaRobert L Charlebois - Program in Evolutionary Biology, Canadian Institute for Advanced Research, National Research Council of Canada, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, CanadaW.Ford Doolittle - Program in Evolutionary Biology, Canadian Institute for Advanced Research, National Research Council of Canada, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, Canada
- Resource Type
- Journal article
- Publication Details
- FEMS microbiology letters, Vol.144(2), pp.151-155
- DOI
- 10.1016/0378-1097(96)00351-5
- PMID
- 8900058
- NLM abbreviation
- FEMS Microbiol Lett
- ISSN
- 0378-1097
- eISSN
- 1574-6968
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1996
- Academic Unit
- Biology
- Record Identifier
- 9984217423402771
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