An assessment of radionuclidic impurities of (210)Po produced via neutron irradiation of (209)Bi for use in targeted alpha-particle radiotherapy

Michael K Schultz; Mark P Borgman; Tomika Coleman; Sergei Bakhlanov; Nikolai Marchenkov; Bruce R Line

doi:10.1016/j.apradiso.2007.03.005

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An assessment of radionuclidic impurities of (210)Po produced via neutron irradiation of (209)Bi for use in targeted alpha-particle radiotherapy

Journal article

Peer reviewed

An assessment of radionuclidic impurities of (210)Po produced via neutron irradiation of (209)Bi for use in targeted alpha-particle radiotherapy

Michael K Schultz, Mark P Borgman, Tomika Coleman, Sergei Bakhlanov, Nikolai Marchenkov and Bruce R Line

Applied radiation and isotopes, Vol.65(7), pp.784-792

07/2007

DOI: 10.1016/j.apradiso.2007.03.005

PMID: 17466524

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Abstract

Radionuclidic impurities of (210)Po prepared by neutron irradiation of (209)Bi via the (209)Bi(n,gamma)(210)Bi reaction were investigated. Following irradiation and ingrowth, a pure (210)Po solution was obtained by sublimation and dissolution. Results were obtained by liquid scintillation (LS) counting, isotope dilution alpha (alpha)-spectrometry, and high-purity germanium gamma-ray spectrometry. No alpha-emitting (3-10MeV) or gamma-emitting (30-3600keV) impurities were detected, with calculated lower limits of detection for impurities of approximately 0.01% (210)Po activity. LS spectra revealed no identifiable beta-emitting impurity. LS sources prepared using Opti-Phase 'Hi Safe' III and Opti-Fluor LS cocktails were stable over a 4-day multi-cycle counting period for (210)Po dissolved in 0.1% trifluoracetic acid (pH approximately 2, water fraction approximately 2%). The radioactivity concentration determined by LS counting was verified by isotope dilution alpha spectrometry. These results suggest that neutron irradiation of (209)Bi (followed by sublimation) can produce (210)Po in a highly pure form that is suitable for radiopharmaceutical preparations.

Bismuth - chemistry

Polonium - analysis

Polonium - therapeutic use

Alpha Particles

Neutrons

Radiopharmaceuticals - analysis

Radioisotopes - chemistry

Radiopharmaceuticals - therapeutic use

Details

Title: Subtitle: An assessment of radionuclidic impurities of (210)Po produced via neutron irradiation of (209)Bi for use in targeted alpha-particle radiotherapy
Creators: Michael K Schultz - National Institute of Standards and Technology, Nuclear Medicine Standards Program, 100 Bureau Drive MS 8462, Gaithersburg, MD 20899, USA. michael-schultz@uiowa.edu
Mark P Borgman
Tomika Coleman
Sergei Bakhlanov
Nikolai Marchenkov
Bruce R Line
Resource Type: Journal article
Publication Details: Applied radiation and isotopes, Vol.65(7), pp.784-792
Publisher: England
DOI: 10.1016/j.apradiso.2007.03.005
PMID: 17466524
ISSN: 0969-8043
eISSN: 1872-9800
Language: English
Date published: 07/2007
Academic Unit: Radiology; Stead Family Department of Pediatrics; Radiation Oncology
Record Identifier: 9984047603302771

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