Journal article
An association study of PCQAP polymorphisms and schizophrenia
Psychiatric genetics, Vol.14(3), pp.169-172
09/2004
DOI: 10.1097/00041444-200409000-00010
PMID: 15318033
Abstract
PCQAP is a member of the mediator family of transcription co-activators that is found in the region of 22q11, which is consistently deleted in DiGeorges/velocranialfacial (VCF) syndrome. As such, it is a gene of interest to behavioral geneticists because VCF is also associated with a high rate of psychosis and because defects in other mediator genes have been linked to psychosis and abnormal neurodevelopmental abnormalities. Recently, DeLuca and colleagues reported that polymorphisms in a trinucleotide repeat in exon 7 of PCQAP were associated with schizophrenia in a case-control study of Italian schizophrenics.
To confirm and extend the prior findings, we conducted a case-control association analysis using DNA from 233 schizophrenics and 371 random controls.
Unfortunately, we did not find any significant differences in the distribution of CAG repeat alleles between subjects and controls.
These findings limit the role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia.
Details
- Title: Subtitle
- An association study of PCQAP polymorphisms and schizophrenia
- Creators
- Harinder K Sandhu - Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242-1000, USANancy HollenbeckThomas H WassinkRobert A Philibert
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.14(3), pp.169-172
- DOI
- 10.1097/00041444-200409000-00010
- PMID
- 15318033
- NLM abbreviation
- Psychiatr Genet
- ISSN
- 0955-8829
- eISSN
- 1473-5873
- Publisher
- England
- Grant note
- K-08MH62123-01 / NIMH NIH HHS K08MH064714 / NIMH NIH HHS
- Language
- English
- Date published
- 09/2004
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003950802771
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