Journal article
An early favorable outcome of streptococcal toxic shock syndrome may require a combination of antimicrobial and intravenous gamma globulin therapy together with activated protein C
Scandinavian journal of infectious diseases, Vol.38(11-12), pp.960-963
2006
DOI: 10.1080/00365540500373224
PMID: 17148061
Abstract
Streptococcal toxic shock syndrome (STSS) associated with a group A beta hemolytic streptococcal infection was described 18 y ago. Since then, although the pathophysiology of the syndrome has been clarified, mortality can be as high as 80%. A middle-aged female developed STSS associated with a group A streptococcal pneumonia. Laboratory studies confirmed respiratory and renal failure as well as disseminated intravascular coagulation with a striking reduction in endogenous procoagulants. The patient, probably due to her HLA DRB1*14 haplotype was unable to generate anti-streptococcal antibodies. She was treated with appropriate antimicrobial therapy together with intravenous gamma globulin and drotrecogin or activated protein C. Her response to this combined therapy was accompanied by a rapid resolution of the multiorgan failure and correction of the accompanying disseminated intravascular coagulation. This rapid response to treatment supports the hypohesis that several host factors including the immune response and loss of procoagulants determine the development and severity of the toxic shock syndromes. Further studies with this combined approach appear warranted.
Details
- Title: Subtitle
- An early favorable outcome of streptococcal toxic shock syndrome may require a combination of antimicrobial and intravenous gamma globulin therapy together with activated protein C
- Creators
- Lawrence A Cone - 1From the Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USARichard A Stone - 1From the Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USAPatrick M Schlievert - 2Department of Microbiology, University of Minnesota, Minneapolis, MN, USARonald A Sneider - 1From the Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USAAndrew M Rubin - 1From the Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USAKenneth Jesser - 1From the Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USAStacey W Renker - 1From the Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USA
- Resource Type
- Journal article
- Publication Details
- Scandinavian journal of infectious diseases, Vol.38(11-12), pp.960-963
- Publisher
- Informa UK Ltd
- DOI
- 10.1080/00365540500373224
- PMID
- 17148061
- ISSN
- 0036-5548
- eISSN
- 1651-1980
- Language
- English
- Date published
- 2006
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001204702771
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