Journal article
An elusive adenylate cyclase complicit in cholera is exposed
The Journal of biological chemistry, Vol.293(33), pp.12960-12961
08/17/2018
DOI: 10.1074/jbc.H118.004669
PMCID: PMC6102141
PMID: 30120153
Abstract
The intestinal consequences of cholera enterotoxin are caused by activation of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel through the actions of an as-yet-unknown adenylate cyclase. A new study hunts down this elusive enzyme, showing that mouse and human intestinal epithelium functionally and structurally pair adenylate cyclase isoform 6 (AC6) with CFTR. These findings provide important insights into the molecular mechanisms underlying the robust pathological activation of CFTR activity and promise new opportunities to treat cholera.
Details
- Title: Subtitle
- An elusive adenylate cyclase complicit in cholera is exposed
- Creators
- Christoph O Randak - Stead Family Department of Pediatrics and the Lung Biology and Cystic Fibrosis Research Center of the Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa 52242. Electronic address: christoph-randak@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.293(33), pp.12960-12961
- DOI
- 10.1074/jbc.H118.004669
- PMID
- 30120153
- PMCID
- PMC6102141
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Grant note
- R01 DK107489 / NIDDK NIH HHS
- Language
- English
- Date published
- 08/17/2018
- Academic Unit
- Pulmonary Medicine; Stead Family Department of Pediatrics
- Record Identifier
- 9984093343102771
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