Journal article
An emerging peri-urban pattern of infection with Leishmania chagasi, the protozoan causing visceral leishmaniasis in northeast Brazil
Scandinavian journal of infectious diseases, Vol.36(6-7), pp.443-449
2004
DOI: 10.1080/00365540410020451
PMID: 15307565
Abstract
Peri-urban visceral leishmaniasis (VL) caused by Leishmania chagasi is emerging in a new epidemiologic pattern in Brazilian cities. We studied peri-urban VL in endemic neighborhoods surrounding Natal, Brazil, identified through hospitalized individuals with VL. Clinical and environmental information obtained for 1106 members of 216 families living in endemic neighborhoods enabled us to identify 4 groups: VL: individuals with current or prior symptomatic visceral leishmaniasis (n = 135); DTH+: individuals with positive delayed-type hypersensitivity response with no history of VL (n = 390); Ab +: individuals with negative DTH response and seropositive (n = 21); DTH -: individuals with negative DTH and seronegative (n = 560). The mean +/-SD age of VL was 9.3+/-12.3 y. The gender distribution was nearly equal below age 5, but skewed toward males at higher ages. Acutely infected VL subjects had significantly lower hematocrits, neutrophils, and eosinophils than other categories. AB+ subjects also had lower eosinophil counts than others, a possible immune marker of early infection. VL was not associated with ownership of dogs or other animals, raising the question whether the reservoir differs in peri-urban settings. This new pattern of L. chagasi infection enables us to identify epidemiological and host factors underlying this emerging infectious disease.
Details
- Title: Subtitle
- An emerging peri-urban pattern of infection with Leishmania chagasi, the protozoan causing visceral leishmaniasis in northeast Brazil
- Creators
- Selma M B Jeronimo - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. smbj@cb.ufrn.brPriya DuggalRegina F S BrazChun ChengGloria R G MonteiroEliana T NascimentoDaniella R A MartinsTheresa M KarplusMaria F F M XimenesCarlos C G OliveiraVanessa G PinheiroWogelsanger PereiraJose M PeraltaJacira SousaIara M MedeirosRichard D Pearson - University of VirginiaTrudy L BurnsElizabeth W PughMary E Wilson
- Resource Type
- Journal article
- Publication Details
- Scandinavian journal of infectious diseases, Vol.36(6-7), pp.443-449
- DOI
- 10.1080/00365540410020451
- PMID
- 15307565
- NLM abbreviation
- Scand J Infect Dis
- ISSN
- 0036-5548
- eISSN
- 1651-1980
- Publisher
- England
- Grant note
- AI48822 / NIAID NIH HHS AI-30639 / NIAID NIH HHS TW01369 / FIC NIH HHS AI45540 / NIAID NIH HHS T32 AI07511 / NIAID NIH HHS DK/AI2550 / NIDDK NIH HHS
- Language
- English
- Date published
- 2004
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001112102771
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