Journal article
An emerging role for IQGAP1 in tight junction control
Small GTPases, Vol.9(5), pp.375-383
09/03/2018
DOI: 10.1080/21541248.2016.1244440
PMCID: PMC5997139
PMID: 27880081
Abstract
IQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia.
Details
- Title: Subtitle
- An emerging role for IQGAP1 in tight junction control
- Creators
- Barbara E Tanos - Division of Cancer Therapeutics, The Institute of Cancer ResearchCharles Yeaman - Department of Anatomy and Cell Biology, The University of IowaEnrique Rodriguez-Boulan - Department of Cell and Developmental Biology, Weill Cornell Medical College
- Resource Type
- Journal article
- Publication Details
- Small GTPases, Vol.9(5), pp.375-383
- DOI
- 10.1080/21541248.2016.1244440
- PMID
- 27880081
- PMCID
- PMC5997139
- NLM abbreviation
- Small GTPases
- ISSN
- 2154-1248
- eISSN
- 2154-1256
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 09/03/2018
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984025410502771
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