Journal article
An evaluation of carrier agents for desferoxamine, an up-regulator of vascular endothelial growth factor
Journal of biomaterials applications, Vol.27(8), pp.1046-1054
05/2013
DOI: 10.1177/0885328211433137
PMID: 22262572
Abstract
Avascularity and hypoxia result in avascular necrosis and play a negative role in fracture healing. The FDA-approved iron chelating agent, desferoxamine (DFO) in a liquid form, has been shown to induce angiogenesis and improve fracture healing through upregulation of the vascular endothelial growth factor. We were concerned that local injection of DFO would either fail to adequately deliver sufficient drug to the desired site or lead to undesired delivery to adjacent sites. Therefore, a sustained release delivery system was desirable to direct DFO to the intended site. Calcium sulfate pellets, collagen sponges, and demineralized cortical bone matrix were all evaluated as potentially controlled release systems for DFO using a fetal mouse metatarsal angiogenesis assay. Angiogenesis was analyzed using a vascularity grading scale, by measuring the mean vessel length of the 5 longest vessels, and by counting the mean number of vessels per metatarsal. Although there was some evidence of angiogenesis with all three carriers, DFO loaded CaSO4 pellets increased vascularity grading, the mean length of the five longest vessels, and the mean number of vessels, all by statistically significant margins versus the control. These results suggest that CaSO4 pellets could be used as a viable, nontoxic, controlled release system for DFO in clinical situations where increased angiogenesis and bone growth are desirable.
Details
- Title: Subtitle
- An evaluation of carrier agents for desferoxamine, an up-regulator of vascular endothelial growth factor
- Creators
- Brian P Hertzberg - University of North Carolina School of Medicine, Chapel Hill, NC 27599, USAJoshua B Holt - University of North Carolina School of Medicine, Chapel Hill, NC 27599, USARonald D Graff - Department of Orthopaedic Surgery, University of North Carolina School of Medicine, CB7055, Chapel Hill, NC 27599, USAShawn R Gilbert - Department of Surgery, Division of Orthopedic Surgery, University of Alabama at Birmingham, 1600 7th Avenue South, ACC Suite 316, Birmingham, Alabama, USALaurence E Dahners - Department of Orthopaedic Surgery, University of North Carolina School of Medicine, CB7055, Chapel Hill, NC 27599, USA
- Resource Type
- Journal article
- Publication Details
- Journal of biomaterials applications, Vol.27(8), pp.1046-1054
- DOI
- 10.1177/0885328211433137
- PMID
- 22262572
- ISSN
- 0885-3282
- eISSN
- 1530-8022
- Language
- English
- Date published
- 05/2013
- Academic Unit
- Stead Family Department of Pediatrics; Orthopedics and Rehabilitation
- Record Identifier
- 9984040400102771
Metrics
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