An evaluation of the association between an antimicrobial stewardship score and antimicrobial usage

Amy L Pakyz; Leticia R Moczygemba; Hui Wang; Michael P Stevens; Michael B Edmond

doi:10.1093/jac/dku555

Back

An evaluation of the association between an antimicrobial stewardship score and antimicrobial usage

Journal article

Open access

Peer reviewed

An evaluation of the association between an antimicrobial stewardship score and antimicrobial usage

Amy L Pakyz, Leticia R Moczygemba, Hui Wang, Michael P Stevens and Michael B Edmond

The Journal of antimicrobial chemotherapy, Vol.70(5), pp.1588-1591

05/2015

DOI: 10.1093/jac/dku555

PMCID: PMC4481682

PMID: 25614043

Files and links (1)

url

https://doi.org/10.1093/jac/dku555View

Published (Version of record) Open Access

Abstract

To determine whether an antimicrobial stewardship 'intensity' score predicts hospital antimicrobial usage. An antimicrobial stewardship score for 44 academic medical centres was developed that comprised two main categories: resources (antimicrobial stewardship programme personnel and automated surveillance software) and strategies (preauthorization, audit with intervention and feedback, education, guidelines and clinical pathways, parenteral to oral therapy programmes, de-escalation of therapy, antimicrobial order forms and dose optimization). Multiple regression analyses were used to assess whether the composite score and also the categories were associated with either total or antimicrobial stewardship programme-target antimicrobial use as measured in days of therapy. The mean antimicrobial stewardship programme score was 55 (SD 21); the total composite score was not significantly associated with total or target antimicrobial use [estimate -0.49 (95% CI -2.30 to 0.89)], while the category strategies was significantly and negatively associated with target antimicrobial use [-5.91 (95% CI -9.51 to -2.31)]. The strategy component of a score developed to measure the intensity of antimicrobial stewardship was associated with the amount of antimicrobials used. Thus, the number and types of strategies employed by antimicrobial stewardship programmes may be of particular importance in programme effectiveness.

Anti-Bacterial Agents - therapeutic use

Drug Utilization - standards

Delivery of Health Care - organization & administration

Academic Medical Centers

Health Policy

Humans

Details

Title: Subtitle: An evaluation of the association between an antimicrobial stewardship score and antimicrobial usage
Creators: Amy L Pakyz - Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA apakyz@vcu.edu
Leticia R Moczygemba - Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA
Hui Wang - Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Michael P Stevens - Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Michael B Edmond - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: The Journal of antimicrobial chemotherapy, Vol.70(5), pp.1588-1591
DOI: 10.1093/jac/dku555
PMID: 25614043
PMCID: PMC4481682
NLM abbreviation: J Antimicrob Chemother
ISSN: 0305-7453
eISSN: 1460-2091
Publisher: England
Grant note: K08HS018578 / AHRQ HHS
Language: English
Date published: 05/2015
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9983905522202771

Metrics

29 Record Views

20 Times Cited - Web of Science