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An exceptional overall survival using bevacizumab beyond progression in a patient with non-small cell lung cancer
Journal article   Open access   Peer reviewed

An exceptional overall survival using bevacizumab beyond progression in a patient with non-small cell lung cancer

Giandomenico Roviello, Edoardo Francini, Armando Perrella, Letizia Laera, Maria Antonietta Mazzei, Susanna Guerrini and Roberto Petrioli
Cancer biology & therapy, Vol.16(12), pp.1720-1725
12/02/2015
DOI: 10.1080/15384047.2015.1095410
PMCID: PMC4847824
PMID: 26418066
url
https://doi.org/10.1080/15384047.2015.1095410View
Published (Version of record) Open Access

Abstract

Non-small cell lung cancer (NSCLC) is the most common malignancy and the leading cause of cancer death worldwide. In this report, we describe a patient with NSCLC who was treated with continuation of Bevacizumab (Bev) beyond progression to first-line Bev-based chemotherapy. The prolonged treatment with Bev by continuing the inhibition of VEGF beyond first-progression has a strong rationale. Nevertheless, few data exist regarding the efficacy and safety of Bev beyond first line of chemotherapy progression in NSCLC patients. Further studies including a large number of patients are needed, in order to select patients who could benefit from this approach.
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