Journal article
An exploratory analysis of go/nogo event-related potentials in major depression and depression following traumatic brain injury
Psychiatry research. Neuroimaging, Vol.224(3), pp.324-334
12/30/2014
DOI: 10.1016/j.pscychresns.2014.09.008
PMID: 25452196
Abstract
Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are estimated to be between 20% and 45%, a higher prevalence than that seen in the general population. These increased rates may be due to specific changes in brain function following TBI. Event related potentials (ERPs) are well suited for measuring the electrophysiological differences between groups in areas of cognitive processing impaired in both MDD and TBI, such as response inhibition. The current study presented an emotional Go/Nogo task (with schematic emotional faces as stimuli) to participants with TBI, participants with MDD, and participants with both TBI and MDD (TBI-MDD). Topographical distribution of activity and global field power comparisons were made across stimulus locked epochs between these groups and healthy controls. The results indicated that ERPs were not altered by TBI alone. Both MDD and TBI-MDD groups showed similar alterations in topographical distribution and global field power in the N2 window, as well as late epoch alterations. The MDD and TBI-MDD groups showed significantly less fronto-central negativity during the N2 window in Nogo trials compared with the control group. The MDD and TBI-MDD groups also showed significantly less global field power in Nog trials than Go trials during the N2 window while the control group showed the opposite pattern. The MDD and TBI-MDD groups showed no mood-congruent bias in behavioural or ERP measures. The results suggest that TBIMDD displays similar electrophysiological changes to those found in the MDD group without TBI. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- An exploratory analysis of go/nogo event-related potentials in major depression and depression following traumatic brain injury
- Creators
- Neil W. Bailey - Monash Alfred Psychiatry Research centreKate E. Hoy - Monash Alfred Psychiatry Research centreJerome J. Maller - Monash Alfred Psychiatry Research centreRebecca A. Segrave - Monash Alfred Psychiatry Research centreRichard Thomson - Monash UniversityNicholas Williams - Monash UniversityZafiris J. Daskalakis - Centre for Addiction and Mental HealthPaul B. Fitzgerald - Monash Alfred Psychiatry Research centre
- Resource Type
- Journal article
- Publication Details
- Psychiatry research. Neuroimaging, Vol.224(3), pp.324-334
- DOI
- 10.1016/j.pscychresns.2014.09.008
- PMID
- 25452196
- NLM abbreviation
- Psychiatry Res Neuroimaging
- ISSN
- 0925-4927
- eISSN
- 1872-7506
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- National Health and Medical Research Council (NHMRC), Australia; National Health & Medical Research Council (NHMRC) of Australia NHMRC Fellowship; National Health & Medical Research Council (NHMRC) of Australia Monash University Victorian Neurotrauma Initiative NHMRC; National Health & Medical Research Council (NHMRC) of Australia CIHR Clinician Scientist Award; Canadian Institutes of Health Research (CIHR)
- Language
- English
- Date published
- 12/30/2014
- Academic Unit
- Radiology
- Record Identifier
- 9984848427102771
Metrics
6 Record Views