Journal article
An immunological panacea for cancer-related cachexia
Trends in cancer
06/24/2026
DOI: 10.1016/j.trecan.2026.06.005
PMID: 42342529
Abstract
Cancer cachexia, responsible for up to 30% of cancer deaths, has transitioned conceptually from a mere nutritional deficit into a highly coordinated, multi-organ immunometabolic network that systematically dismantles host homeostasis. This review synthesizes the paradigm-shifting discoveries that position the immune system as the central conductor of tissue wasting. We delineate how redundant inflammatory cascades, neuro-immune circuits, and local cellular plasticity converge to drive muscle and adipose catabolism. Furthermore, we dissect the metabolic competition for nutrients between tumor cells and host immunity, which accelerates structural degradation. Finally, we highlight how single-cell multiomics, spatial transcriptomics, and artificial intelligence are redefining clinical stratification, shifting the therapeutic horizon toward individualized, multi-node immunometabolic interventions, thereby providing a theoretical framework for the management of cachectic wasting syndrome.
Details
- Title: Subtitle
- An immunological panacea for cancer-related cachexia
- Creators
- Jingyu Xue - Sichuan UniversityTianyi Lu - Sichuan UniversityKailin Yang - Cleveland ClinicAlexander Birbrair - University of Wisconsin–MadisonShengtao Zhou - Sichuan University
- Resource Type
- Journal article
- Publication Details
- Trends in cancer
- DOI
- 10.1016/j.trecan.2026.06.005
- PMID
- 42342529
- NLM abbreviation
- Trends Cancer
- ISSN
- 2405-8025
- eISSN
- 2405-8025
- Publisher
- Elsevier
- Language
- English
- Electronic publication date
- 06/24/2026
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9985176655402771
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