An in vitro comparative study determining bactericidal activity of stabilized chlorine dioxide and other oral rinses

David Drake; Alissa L Villhauer

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An in vitro comparative study determining bactericidal activity of stabilized chlorine dioxide and other oral rinses

Journal article

Peer reviewed

An in vitro comparative study determining bactericidal activity of stabilized chlorine dioxide and other oral rinses

David Drake and Alissa L Villhauer

The Journal of clinical dentistry, Vol.22(1), pp.1-5

2011

PMID: 21290979

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Abstract

The study was conducted to determine the bactericidal activity of a stabilized chlorine dioxide oral rinse (ClōSYS Oral Rinse) compared to products currently available on the market. Oral bacteria associated with gingivitis and periodontitis were exposed to rinses for one minute and five minutes. The numbers of colony forming units per milliliter (CFU/ml) were measured prior to and following exposure to determine the bactericidal activity. As expected, Listerine and Crest Pro-Health demonstrated complete kill on all bacteria exposed within one minute. Breath Rx exhibited the weakest levels of bactericidal effects overall. ClōSYS and chlorhexidine rinses proved identical 100% kills against the periodontal pathogens at five minutes; in some cases, ClōSYS oral rinse achieved a higher kill at the one-minute mark over the chlorhexidine rinse. The results demonstrated that ClōSYS Oral Rinse has potential for providing a therapeutic benefit, making it an attractive option to induce compliance in patients concerned about taste and tooth discoloration during oral health therapy.

Actinomyces - classification

Enterococcus faecalis - drug effects

Klebsiella pneumoniae - drug effects

Peptostreptococcus - drug effects

Periodontitis - microbiology

Haemophilus influenzae - drug effects

Humans

Gingivitis - microbiology

Chlorhexidine - pharmacology

Streptococcus - drug effects

Salicylates - pharmacology

Terpenes - pharmacology

Time Factors

Aggregatibacter actinomycetemcomitans - drug effects

Prevotella nigrescens - drug effects

Actinomyces - drug effects

Anti-Infective Agents, Local - pharmacology

Materials Testing

Streptococcus mutans - drug effects

Bacterial Load

Pseudomonas aeruginosa - drug effects

Cetylpyridinium - pharmacology

Streptococcus oralis - drug effects

Mouthwashes - pharmacology

Oxides - pharmacology

Chlorine Compounds - pharmacology

Anti-Bacterial Agents - pharmacology

Staphylococcus aureus - drug effects

Drug Combinations

Porphyromonas gingivalis - drug effects

Details

Title: Subtitle: An in vitro comparative study determining bactericidal activity of stabilized chlorine dioxide and other oral rinses
Creators: David Drake - Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USA. david-drake@uiowa.edu
Alissa L Villhauer
Resource Type: Journal article
Publication Details: The Journal of clinical dentistry, Vol.22(1), pp.1-5
Publisher: United States
PMID: 21290979
ISSN: 0895-8831
Language: English
Date published: 2011
Academic Unit: Endodontics; Dental Research
Record Identifier: 9984066080002771

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