Journal article
An in vitro evaluation of cone-beam breast CT methods
Journal of X-ray science and technology, Vol.16(3), pp.171-187
10/01/2008
PMCID: PMC2855164
PMID: 20401330
Abstract
Tomosynthesis was developed for mammography, especially breast cancer detection. However, its limited-angular range scan and resultant data incompleteness causes strong image artifacts and distortions. To address this problem, a hybrid imaging method was proposed in our previous work, which combines tomosynthesis and low-resolution CT into a single system to produce fewer artifacts and distortions at a similar dose level. The purpose of this paper is to evaluate the images reconstructed using the proposed method as compared with that using the conventional tomosynthesis method (ML-convex). For that purpose, the projection datasets are acquired in both numerical simulation and phantom experiments on our breast imaging platform. Three kinds of phantoms are used in our work, including a numerical phantom, a physical phantom and 8
in vitro
phantoms made of breast specimens. In addition to visual comparison of the reconstructed images, we employ spatial resolution, image contrast, reconstruction error, and convergence rate to evaluate the results quantitatively. It is observed that the results from our method can achieve significantly higher spatial resolution, higher contrast, smaller reconstruction error and faster convergence rate. Besides, a reader study using 8
in vitro
phantoms of breast specimens demonstrates the clinical potential of our method, which significantly outperforms the conventional tomosynthesis.
Details
- Title: Subtitle
- An in vitro evaluation of cone-beam breast CT methods
- Creators
- Kai Zeng - Biomedical Engineering Department, The University of Iowa, Iowa city, IA 52242, USALaurie L Fajardo - Radiology Department, The University of Iowa, Iowa city, IA 52242, USASimon Kao - Radiology Department, The University of Iowa, Iowa city, IA 52242, USAEdmund A Franken - Radiology Department, The University of Iowa, Iowa city, IA 52242, USAJeong Mi Park - Radiology Department, The University of Iowa, Iowa city, IA 52242, USAZhenxue Jing - Hologic Inc., Bedford, MA 01730, USAEr-wei Bai - Electrical and Computer Engineering Department, The University of Iowa, Iowa City, IA 52242, USAGe Wang - VT-WFU School of Biomedical Engineering & Science, Virginia Polytechnic Institute & State University, VA 24061, USA
- Resource Type
- Journal article
- Publication Details
- Journal of X-ray science and technology, Vol.16(3), pp.171-187
- PMID
- 20401330
- PMCID
- PMC2855164
- ISSN
- 0895-3996
- eISSN
- 1095-9114
- Language
- English
- Date published
- 10/01/2008
- Academic Unit
- Radiology; Electrical and Computer Engineering; Stead Family Department of Pediatrics
- Record Identifier
- 9984051533402771
Metrics
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