Journal article
An in vivo method for the biological evaluation of metal implants
Journal of biomedical materials research, Vol.18(7), pp.829-844
1984
DOI: 10.1002/jbm.820180713
PMID: 6544782
Abstract
The peritoneal cavity of the rat was used as an implantation site in order to study the quantitative, cellular response and the qualitative, histopathological response to three metals (Ag, Sn, Cu). The effects of the metals on the cells were correlated with the cellular concentrations of the metal as determined by chemical analysis. Small variations in the cell population and a minimal foreign body reaction was observed with an implanted control material (silicone polymer). Large increases in the number of cells and an intense foreign body reaction was observed with Cu implants. Decreases in the number of cells were seen with Sn and Ag implants, but only Sn elicited a foreign body reaction. Implantation of Ag failed to elicit a foreign body reaction. Significant concentrations of all three metals were detected in the retrieved cells.
Details
- Title: Subtitle
- An in vivo method for the biological evaluation of metal implants
- Creators
- J. C KELLER - Northwestern univ., dep. biological materials, Chicago IL 60611, United StatesG. W MARSHALL - Northwestern univ., dep. biological materials, Chicago IL 60611, United StatesE. J KAMINSKY - Northwestern univ., dep. biological materials, Chicago IL 60611, United States
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research, Vol.18(7), pp.829-844
- Publisher
- John Wiley & Sons; New York, NY
- DOI
- 10.1002/jbm.820180713
- PMID
- 6544782
- ISSN
- 0021-9304
- eISSN
- 1097-4636
- Language
- English
- Date published
- 1984
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Graduate College Admin and Gen; President; Oral and Maxillofacial Surgery; Dental Research
- Record Identifier
- 9984066095502771
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