An interactive visualization-based approach for high throughput screening information management in drug discovery

Tammy Pui Shan Chan; Preeti Malik; Rahul Singh

doi:10.1109/IEMBS.2006.259448

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Journal article

An interactive visualization-based approach for high throughput screening information management in drug discovery

Tammy Pui Shan Chan, Preeti Malik and Rahul Singh

Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), Vol.2006, pp.5794-5797

2006

DOI: 10.1109/IEMBS.2006.259448

PMID: 17947168

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Abstract

While high throughput screening (HTS) techniques are capable of generating large amounts of biologically significant data, assimilating and mining this information can be extremely complex and potentially crucial information patterns can easily be lost in the mounds of data. The predominantly life-science oriented scientific training of the researchers in this area furthermore, precludes their using complex querying or data-mining algorithms. Keeping in account these challenges, our goal in this paper is to provide a highly intuitive environment for storing and interacting with large amounts of HTS assay data. The principal modes of user-data interactions supported in the proposed paradigm are interaction and visualization rich. Moreover, they span the heterogeneous data modalities common to drug discovery, including but not limited to chemical structures, high-throughput assay formats, graphical information, and alpha-numeric data types. Case studies and experiments demonstrate the efficacy of the proposed approach in terms of its ease of use as well as its capability to discern complex information patterns in the data.

Algorithms

Computer Graphics

Database Management Systems

Drug Design

Humans

Information Management

Information Storage and Retrieval

Molecular Conformation

Pattern Recognition, Automated

Programming Languages

Software

Spectrometry, Fluorescence

Structure-Activity Relationship

Technology, Pharmaceutical

User-Computer Interface

Details

Title: Subtitle: An interactive visualization-based approach for high throughput screening information management in drug discovery
Creators: Tammy Pui Shan Chan - San Francisco State University
Preeti Malik - San Francisco State University
Rahul Singh - San Francisco State University
Resource Type: Journal article
Publication Details: Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), Vol.2006, pp.5794-5797
DOI: 10.1109/IEMBS.2006.259448
PMID: 17947168
ISSN: 1557-170X
Language: English
Date published: 2006
Academic Unit: Computer Science
Record Identifier: 9984446062202771

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