An objective method to define outlier optical coherence tomograms and repeatability of retinal nerve fibre layer measurements

Oliver Bergamin; Susan C Anderson; Randy H Kardon

doi:10.1111/j.1600-0420.2004.00316.x

Back

An objective method to define outlier optical coherence tomograms and repeatability of retinal nerve fibre layer measurements

Journal article

Open access

An objective method to define outlier optical coherence tomograms and repeatability of retinal nerve fibre layer measurements

Oliver Bergamin, Susan C Anderson and Randy H Kardon

Acta ophthalmologica Scandinavica, Vol.82(5), pp.535-543

10/2004

DOI: 10.1111/j.1600-0420.2004.00316.x

PMID: 15453849

Files and links (1)

url

https://doi.org/10.1111/j.1600-0420.2004.00316.xView

Published (Version of record) Open Access

Abstract

To compare the variation in thickness and reflectivity of the retinal nerve fibre layer (RNFL), circumferentially and on repeated testing. In 24 normal eyes and 38 eyes with different optic neuropathies or retinopathies, third-party optical coherence tomography (OCT) software defined the RNFL border based on the reflectivity pattern across the retina and also provided measurements of the mean reflectivity and total retinal thickness in addition to RNFL thickness. A new Gaussian filtering method was implemented so that the weight of the applied filter was varied for each of five individually repeated scans until an optimum weight filter was determined. The scans requiring the highest weight filter could be identified as 'outlier' scans that contained measurement or alignment artifacts. There was no difference in the weights of filtering needed for normal and abnormal eyes. The RNFL thickness and reflectivity, and retinal thickness were highly correlated with one another in normal and abnormal eyes. A new Gaussian filtering routine was devised that not only defined the most reproducible substructure of the RNFL for a given patient's eye, but also provided a new method of quantifying measurement variability and identification of scans with measurement or alignment artifacts.

Nerve Fibers - pathology

Reproducibility of Results

Tomography, Optical Coherence

Humans

Middle Aged

Case-Control Studies

Optic Nerve Diseases - pathology

Image Processing, Computer-Assisted

Retinal Diseases - pathology

Adult

Aged

Software

Retina - pathology

Details

Title: Subtitle: An objective method to define outlier optical coherence tomograms and repeatability of retinal nerve fibre layer measurements
Creators: Oliver Bergamin - Department of Ophthalmology and Visual Science, Veterans Administration Hospital and University of Iowa, Iowa City, Iowa, USA. oliver.bergamin@usz.ch
Susan C Anderson
Randy H Kardon
Resource Type: Journal article
Publication Details: Acta ophthalmologica Scandinavica, Vol.82(5), pp.535-543
DOI: 10.1111/j.1600-0420.2004.00316.x
PMID: 15453849
NLM abbreviation: Acta Ophthalmol Scand
ISSN: 1395-3907
eISSN: 1600-0420
Publisher: Denmark
Language: English
Date published: 10/2004
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980083602771

Metrics

36 Record Views

2 Times Cited - Web of Science