Journal article
An open source, 3D printed preclinical MRI phantom for repeated measures of contrast agents and reference standards
Biomedical physics & engineering express, Vol.4(2), p.27005
01/25/2018
DOI: 10.1088/2057-1976/aa9491
PMCID: PMC5790173
PMID: 29399370
Abstract
In medical imaging, clinicians, researchers and technicians have begun to use 3D printing to create specialized phantoms to replace commercial ones due to their customizable and iterative nature. Presented here is the design of a 3D printed open source, reusable magnetic resonance imaging (MRI) phantom, capable of flood-filling, with removable samples for measurements of contrast agent solutions and reference standards, and for use in evaluating acquisition techniques and image reconstruction performance. The phantom was designed using SolidWorks, a computer-aided design software package. The phantom consists of custom and off-the-shelf parts and incorporates an air hole and Luer Lock system to aid in flood filling, a marker for orientation of samples in the filled mode and bolt and tube holes for assembly. The cost of construction for all materials is under $90. All design files are open-source and available for download. To demonstrate utility, B(0) field mapping was performed using a series of gadolinium concentrations in both the unfilled and flood-filled mode. An excellent linear agreement (R(2)>0.998) was observed between measured relaxation rates (R(1)/R(2)) and gadolinium concentration. The phantom provides a reliable setup to test data acquisition and reconstruction methods and verify physical alignment in alternative nuclei MRI techniques (e.g. carbon-13 and fluorine-19 MRI). A cost-effective, open-source MRI phantom design for repeated quantitative measurement of contrast agents and reference standards in preclinical research is presented. Specifically, the work is an example of how the emerging technology of 3D printing improves flexibility and access for custom phantom design.
Details
- Title: Subtitle
- An open source, 3D printed preclinical MRI phantom for repeated measures of contrast agents and reference standards
- Creators
- B L CoxK D LudwigE B AdamsonK W EliceiriS B Fain
- Resource Type
- Journal article
- Publication Details
- Biomedical physics & engineering express, Vol.4(2), p.27005
- DOI
- 10.1088/2057-1976/aa9491
- PMID
- 29399370
- PMCID
- PMC5790173
- NLM abbreviation
- Biomed Phys Eng Express
- ISSN
- 2057-1976
- eISSN
- 2057-1976
- Grant note
- name: Morgridge Institute for Research; DOI: 10.13039/100005902, name: University of Wisconsin-Madison Institute for Clinical and Translational Research, National Institutes of Health, National Center for Advancing Translational Sciences Awards, award: TL1TR000429, UL1TR000427; name: General Electric Healthcare; DOI: 10.13039/100008258, name: Hyundai Hope On Wheels; name: University of Wisconsin-Madison Radiological Sciences Training Grant; name: National Institutes of Health, National Cancer Institute Award, award: T32CA009206
- Language
- English
- Date published
- 01/25/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984275059902771
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