An overview of characteristics of registered studies on dental implants

Praveenkumar Gajendrareddy; Satheesh Elangovan; Sankeerth Rampa; Veeratrishul Allareddy; Min Kyeong Lee; Romesh P Nalliah; Veerasathpurush Allareddy

doi:10.1016/j.jebdp.2014.06.003

Journal article

An overview of characteristics of registered studies on dental implants

Praveenkumar Gajendrareddy, Satheesh Elangovan, Sankeerth Rampa, Veeratrishul Allareddy, Min Kyeong Lee, Romesh P Nalliah and Veerasathpurush Allareddy

The journal of evidence-based dental practice, Vol.14(3), pp.111-117

09/2014

DOI: 10.1016/j.jebdp.2014.06.003

PMID: 25234209

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Abstract

Clinical trials serve as the empirical basis for clinical decision making. The objective of the current study is to provide an overview of clinical trials examining dental implant outcomes. All registered studies on Dental Implants were selected for analysis. The clinicaltrials.gov<http://clinicaltrials.gov/> website was used to query the characteristics of registered studies. The search term used was dental implants. As of the study conduct date (01/01/2014), a total of 205 studies on dental implants were registered. These included 168 interventional and 37 observational studies. Results were available for only 14 studies. All observational studies and 98.8% of interventional studies included both male and female subjects. Close to 60% of studies had sample sizes between 1 and 50. NIH was listed as funding source in only 5 interventional studies and 3 observational studies. 80% of interventional studies were randomized. However, double masking was reported in only 15% of interventional studies with majority being open labeled. ClinicalTrials.gov registry was created with the intention of increasing the transparency of conducted or ongoing clinical studies and to minimize publication bias commonly seen with industry-sponsored studies. Results of the current study showed that a predominating number of registered studies are funded by industry and other sources, very few registered studies have made their results public, and the ClinicalTrials.gov registry does not provide sufficient information on the quality of study design and thus precluding the public and researchers to judge on the quality of registered studies and publication bias.

Single-Blind Method

Age Factors

Double-Blind Method

United States

Humans

Clinical Trials as Topic - classification

Male

Treatment Outcome

Patient Selection

Randomized Controlled Trials as Topic - standards

Research Support as Topic

National Institutes of Health (U.S.)

Sample Size

Observational Studies as Topic

Adult

Female

Registries

Research Design - standards

Aged

Clinical Trials as Topic - standards

Dental Implants

Child

Details

Title: Subtitle: An overview of characteristics of registered studies on dental implants
Creators: Praveenkumar Gajendrareddy - Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
Satheesh Elangovan - Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA, USA
Sankeerth Rampa - Texas A and M University, College Station, TX, USA
Veeratrishul Allareddy - Department of Oral Pathology, Radiology and Medicine, College of Dentistry, The University of Iowa, Iowa City, IA, USA
Min Kyeong Lee - Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Romesh P Nalliah - Office of Global Health, Harvard School of Dental Medicine, Boston, MA, USA
Veerasathpurush Allareddy - Department of Orthodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA. Electronic address: Veerasathpurush-Allareddy@uiowa.edu
Resource Type: Journal article
Publication Details: The journal of evidence-based dental practice, Vol.14(3), pp.111-117
Publisher: United States
DOI: 10.1016/j.jebdp.2014.06.003
PMID: 25234209
ISSN: 1532-3382
eISSN: 1532-3390
Language: English
Date published: 09/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Oral Pathology, Radiology and Medicine; Pharmaceutical Sciences and Experimental Therapeutics; Periodontics
Record Identifier: 9984065719502771

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