Journal article
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Free radical biology & medicine, Vol.99, pp.544-556
10/2016
DOI: 10.1016/j.freeradbiomed.2016.09.010
PMID: 27634172
Abstract
The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a wide array of genes for antioxidant and detoxification enzymes in response to oxidative and xenobiotic stress. A large number of Nrf2-antioxidant response element (ARE) activators have been screened for use as chemopreventive agents in oxidative stress-related diseases and even cancer. However, constitutive activation of Nrf2 occurs in a variety of cancers. Aberrant activation of Nrf2 is correlated with cancer progression, chemoresistance, and radioresistance. In this review, we examine recent studies of Nrf2-ARE inhibitors in the context of cancer therapy. We enumerate the possible Nrf2-inhibiting mechanisms of these compounds, their effects sensitizing cancer cells to chemotherapeutic agents, and the prospect of applying them in clinical cancer therapy.
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Details
- Title: Subtitle
- An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
- Creators
- Jiayu Zhu - China Medical UniversityHuihui Wang - China Medical UniversityFeng Chen - China Medical UniversityJingqi Fu - China Medical UniversityYuanyuan Xu - China Medical UniversityYongyong Hou - China Medical UniversityHenry H. Kou - China Medical UniversityCheng Zhai - China Medical UniversityM. Bud Nelson - Research Triangle Park FoundationQiang Zhang - Emory UniversityMelvin E. Andersen - The Hamner Institutes for Health SciencesJingbo Pi - China Medical University
- Resource Type
- Journal article
- Publication Details
- Free radical biology & medicine, Vol.99, pp.544-556
- DOI
- 10.1016/j.freeradbiomed.2016.09.010
- PMID
- 27634172
- NLM abbreviation
- Free Radic Biol Med
- ISSN
- 0891-5849
- eISSN
- 1873-4596
- Publisher
- Elsevier Inc
- Grant note
- name: Chinese Nature Science Foundation, award: 81502841, 81573187, 81573106; name: China Medical University, China; name: Liaoning Pandeng Scholar; name: National Key Technology Research and Development Program, award: 2014BAI12B02
- Language
- English
- Date published
- 10/2016
- Academic Unit
- Neurology
- Record Identifier
- 9984302200402771
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