An overview of host immune responses against Leishmania spp. infections

Hanna Paton; Prabuddha Sarkar; Prajwal Gurung

doi:10.1093/hmg/ddaf043

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An overview of host immune responses against Leishmania spp. infections

Journal article

Open access

Peer reviewed

An overview of host immune responses against Leishmania spp. infections

Hanna Paton, Prabuddha Sarkar and Prajwal Gurung

Human molecular genetics, Vol.34(R1), pp.R83-R109

10/07/2025

DOI: 10.1093/hmg/ddaf043

PMCID: PMC12501981

PMID: 40287829

Appears in UI Libraries Support Open Access

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Abstract

Leishmania spp. infections pose a significant global health challenge, affecting approximately 1 billion people across more than 88 endemic countries. This unicellular, obligate intracellular parasite causes a spectrum of diseases, ranging from localized cutaneous lesions to systemic visceral infections. Despite advancements in modern medicine and increased understanding of the parasite's etiology and associated diseases, treatment options remain limited to pentavalent antimonials, liposomal amphotericin B, and miltefosine. A deeper understanding of the interactions between immune and non-immune cells involved in the clearance of Leishmania spp. infections could uncover novel therapeutic strategies for this debilitating disease. This review highlights recent progress in elucidating how various cell types contribute to the regulation and resolution of Leishmania spp. infections.

Parasite

Immune response

Leishmania

Host-pathogen interaction

UIOWA OA Agreement

Details

Title: Subtitle: An overview of host immune responses against Leishmania spp. infections
Creators: Hanna Paton - University of Iowa
Prabuddha Sarkar - University of Iowa, Internal Medicine
Prajwal Gurung - Iowa City Veterans Affairs (VA) Medical Center, 601 US-6, Iowa City, IA 52246, United States
Resource Type: Journal article
Publication Details: Human molecular genetics, Vol.34(R1), pp.R83-R109
DOI: 10.1093/hmg/ddaf043
PMID: 40287829
PMCID: PMC12501981
NLM abbreviation: Hum Mol Genet
ISSN: 1460-2083
eISSN: 1460-2083
Publisher: Oxford University Press
Grant note: University of Iowa Startup Funds T32AI007511 / NIH Training in Mechanisms of Parasitism T32 I01BX006091 / VA Merit Review Award VA R01AI155425 / NIH HHS
Language: English
Electronic publication date: 04/27/2025
Date published: 10/07/2025
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9984816016702771

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