Journal article
An unusual laryngeal mass: primary tumoral calcinosis of the larynx in a child
Otolaryngology case reports, Vol.37, 100710
11/2025
DOI: 10.1016/j.xocr.2025.100710
Abstract
Tumoral calcinosis (TC) is a rare, benign calcium hydroxyapatite deposition typically affecting periarticular tissue of large joints, which may occur sporadically or in association with hyperphosphatemia. Laryngeal TC has been reported in several patients, uniformly in the fifth and sixth decade of life. Presented is a case of sporadic combined intra-laryngeal and extra-laryngeal TC in a child.
A 10-year-old female presented with a right neck mass and stridor with activity. Flexible laryngoscopy revealed fullness of the right false vocal fold without intraluminal mass, and computed tomography showed a large, calcified, intra- and extra-laryngeal mass passing through the thyrohyoid space. Open resection was performed. Surgical pathology revealed TC. Laboratory and endocrine evaluation did not reveal any underlying metabolic etiology, supporting a diagnosis of primary laryngeal TC. Airway management, approach to resection, and published cases of laryngeal TC are reviewed.
TC of the larynx is an exceedingly rare entity. Given benign nature of this disease process, a conservative approach is favored when resection is pursued, with preservation of normal structures in order to minimize morbidity. Upon diagnosis, multidisciplinary evaluation should be pursued to rule out underlying endocrine, metabolic, and genetic disorders.
•Tumoral calcinosis is a rare deposition of calcium hydroxyapatite in periarticular soft tissues.•We report a case of combined intra-laryngeal and extra-laryngeal tumoral calcinosis in a child.•Diagnostic approach, airway management, and surgical techniques are reviewed.
Details
- Title: Subtitle
- An unusual laryngeal mass: primary tumoral calcinosis of the larynx in a child
- Creators
- Miles J. Klimara - University of IowaEirene Alexandrou - University of IowaAnand Kanagasabapathy - University of IowaMatthew R. Hoffman - Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Otolaryngology case reports, Vol.37, 100710
- DOI
- 10.1016/j.xocr.2025.100710
- ISSN
- 2468-5488
- eISSN
- 2468-5488
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 11/2025
- Academic Unit
- Communication Sciences and Disorders; Endocrinology and Diabetes; Stead Family Department of Pediatrics; Pathology; Otolaryngology
- Record Identifier
- 9985027466402771
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