Analgesic Effect of Intra-Articular Injection of Temperature-Responsive Hydrogel Containing Bupivacaine on Osteoarthritic Pain in Rats

Taemin Kim; Dong Rim Seol; Suk-Chan Hahm; Cheolwoong Ko; Eun-Hye Kim; Keyoungjin Chun; Junesun Kim; Tae-Hong Lim

doi:10.1155/2015/812949

Back

Analgesic Effect of Intra-Articular Injection of Temperature-Responsive Hydrogel Containing Bupivacaine on Osteoarthritic Pain in Rats

Journal article

Open access

Peer reviewed

Analgesic Effect of Intra-Articular Injection of Temperature-Responsive Hydrogel Containing Bupivacaine on Osteoarthritic Pain in Rats

Taemin Kim, Dong Rim Seol, Suk-Chan Hahm, Cheolwoong Ko, Eun-Hye Kim, Keyoungjin Chun, Junesun Kim and Tae-Hong Lim

BioMed research international, Vol.2015, 812949

2015

DOI: 10.1155/2015/812949

PMCID: PMC4735994

PMID: 26881207

Files and links (1)

url

https://doi.org/10.1155/2015/812949View

Published (Version of record) Open Access

Abstract

The present study examined the analgesic effects of slow-releasing bupivacaine from hydrogel on chronic arthritic pain in rats. Osteoarthritis (OA) was induced by monosodium iodoacetate (MIA) injection into the right knee joint. Hydrogel (HG: 20, 30, and 50 μ L) and temperature-sensitive hydrogel containing bupivacaine (T-gel: 20, 30, and 50 μ L) were injected intra-articularly 14 days after MIA injection. Behavioral tests were conducted. The rats showed a significant decrease in weight load and paw withdrawal threshold (PWT). Intra-articular 0.5% bupivacaine (10 and 20 μ L) significantly reversed MIA-induced decreased PWT, with no effect on weight load. In normal rats, hydrogel did not produce significant changes in PWT but at 30 and 50 μ L slightly decreased weight bearing; T-gel did not cause any changes in both the weight load and PWT. In OA rats, T-gel at 20 μ L had a significant analgesic effect for 2 days, even though T-gel at 50 μ L further reduced the weight load, demonstrating that intra-articular T-gel (20 μ L) has long-lasting analgesic effects in OA rats. Thus, T-gel designed to deliver analgesics into the joint cavity could be an effective therapeutic tool in the clinical setting.

Details

Title: Subtitle: Analgesic Effect of Intra-Articular Injection of Temperature-Responsive Hydrogel Containing Bupivacaine on Osteoarthritic Pain in Rats
Creators: Taemin Kim - Department of Physical Therapy, Korea University College of Health Science, Seoul 136-713, Republic of Korea
Dong Rim Seol - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
Suk-Chan Hahm - Department of Physical Therapy, Korea University College of Health Science, Seoul 136-713, Republic of Korea
Cheolwoong Ko - Advanced Biomedical and Welfare Group, Korea Institute of Industrial Technology (KITECH), Chungnam 330-825, Republic of Korea
Eun-Hye Kim - Rehabilitation Science Program, Department of Public Health Science, Graduate School, Korea University, Seoul 136-713, Republic of Korea
Keyoungjin Chun - Advanced Biomedical and Welfare Group, Korea Institute of Industrial Technology (KITECH), Chungnam 330-825, Republic of Korea
Junesun Kim - Department of Physical Therapy, Korea University College of Health Science, Seoul 136-713, Republic of Korea
Tae-Hong Lim - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: BioMed research international, Vol.2015, 812949
DOI: 10.1155/2015/812949
PMID: 26881207
PMCID: PMC4735994
NLM abbreviation: Biomed Res Int
ISSN: 2314-6133
eISSN: 2314-6141
Publisher: Hindawi Publishing Corporation
Grant note: DOI: 10.13039/501100003725, name: National Research Foundation of Korea, award: 2012-0003901, K1508371
Language: English
Date published: 2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthodontics; Orthopedics and Rehabilitation
Record Identifier: 9984064257502771

Metrics

24 Record Views

21 Times Cited - Web of Science

See more details