Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

Soumitra Guin; Marhiah C. Montoya; Xiaoyu Wang; Robert Zarnowski; David R. Andes; Marvin J. Meyers; Noelle S. Williams; Damian J. Krysan

doi:10.1128/aac.01301-24

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Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

Journal article

Peer reviewed

Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection

Soumitra Guin, Marhiah C. Montoya, Xiaoyu Wang, Robert Zarnowski, David R. Andes, Marvin J. Meyers, Noelle S. Williams and Damian J. Krysan

Antimicrobial agents and chemotherapy, Vol.68(11), e01301-24

11/06/2024

DOI: 10.1128/aac.01301-24

PMCID: PMC11539235

PMID: 39365066

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11539235/pdf/aac.01301-24.pdfView

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Abstract

Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives of the malarial drug mefloquine have broad-spectrum antifungal activity including difficult-to-treat molds and endemic fungi. Pharmacokinetic and efficacy studies of NSC-4377 indicate that it penetrates the central nervous system and is active against Candida auris in vivo. These data strongly support the further development of mefloquine analogs as a potentially new class of antifungal molecules.

Antimicrobial Chemotherapy

Experimental Therapeutics

Details

Title: Subtitle: Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection
Creators: Soumitra Guin - Saint Louis University
Marhiah C. Montoya - University of Iowa
Xiaoyu Wang - The University of Texas Southwestern Medical Center
Robert Zarnowski - University of Wisconsin–Madison
David R. Andes - University of Wisconsin–Madison
Marvin J. Meyers - Saint Louis University
Noelle S. Williams - University of Wisconsin–Madison
Damian J. Krysan - University of Iowa
Contributors: Audrey Odom John (Editor)
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.68(11), e01301-24
DOI: 10.1128/aac.01301-24
PMID: 39365066
PMCID: PMC11539235
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Publisher: American Society for Microbiology
Number of pages: 5
Grant note: NIH: 7593019D0002, R21AI164578
This work was supported, in part, by R21AI164578 (M.J.M. and D.J.K.).
Language: English
Electronic publication date: 10/04/2024
Date published: 11/06/2024
Academic Unit: Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984721144802771

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