Analysis of HIV Type 1 gp41 and Enfuvirtide Susceptibility among Men in the United States Who Were HIV Infected Prior to Availability of HIV Entry Inhibitors

Sarah E Hudelson; Natalia Marlowe; Wei Huang; Robert Bruce; Jessica D Church; Marla Husnik; Deborah Donnell; Thomas Coates; J. Brooks Jackson; Margaret Chesney; Beryl Koblin; Susan H Eshleman

doi:10.1089/aid.2009.0014

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Analysis of HIV Type 1 gp41 and Enfuvirtide Susceptibility among Men in the United States Who Were HIV Infected Prior to Availability of HIV Entry Inhibitors

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Analysis of HIV Type 1 gp41 and Enfuvirtide Susceptibility among Men in the United States Who Were HIV Infected Prior to Availability of HIV Entry Inhibitors

Sarah E Hudelson, Natalia Marlowe, Wei Huang, Robert Bruce, Jessica D Church, Marla Husnik, Deborah Donnell, Thomas Coates, J. Brooks Jackson, Margaret Chesney, …

AIDS research and human retroviruses, Vol.25(7), pp.701-705

07/2009

DOI: 10.1089/aid.2009.0014

PMCID: PMC2746939

PMID: 19552592

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Abstract

We analyzed HIV gp41 from 195 men in the United States who were HIV-1 infected between 1999 and 2002, before enfuvirtide (ENF) was approved for clinical use in the United States. gp41 genotyping results were obtained for 175 samples. None of the samples had major ENF resistance mutations. Six (3.4%) samples had minor ENF resistance mutations in the HR1 region (V38G, N43K, L44M, L45M). Twenty-eight (16%) samples had the N42S polymorphism, which is associated with ENF hypersusceptibility. Accessory mutations in the HR2 region were identified in some samples (E137K, S138A). Five of the six samples with HR1 resistance mutations were analyzed with a phenotypic assay; one sample had reduced ENF susceptibility (a sample with N42S + L44M + E137K). Prior to the availability of ENF, some men in the United States were infected with HIV that contained mutations associated with ENF resistance or hypersusceptibility. However, most of the mutations were not associated with phenotypic ENF resistance.

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Title: Subtitle: Analysis of HIV Type 1 gp41 and Enfuvirtide Susceptibility among Men in the United States Who Were HIV Infected Prior to Availability of HIV Entry Inhibitors
Creators: Sarah E Hudelson - Department of Pathology
Natalia Marlowe - Celera, Alameda, California 94502
Wei Huang - Monogram Biosciences, South San Francisco, California 94080
Robert Bruce - Celera, Alameda, California 94502
Jessica D Church - Department of Pathology
Marla Husnik - Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Seattle, Washington 98109
Deborah Donnell - Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Seattle, Washington 98109
Thomas Coates - , Los Angeles, California 90024
J. Brooks Jackson - Department of Pathology
Margaret Chesney - , Maryland 21201
Beryl Koblin - New York Blood Center, New York, New York 10022
Susan H Eshleman - Department of Pathology
Resource Type: Journal article
Publication Details: AIDS research and human retroviruses, Vol.25(7), pp.701-705
DOI: 10.1089/aid.2009.0014
PMID: 19552592
PMCID: PMC2746939
NLM abbreviation: AIDS Res Hum Retroviruses
ISSN: 0889-2229
eISSN: 1931-8405
Publisher: Mary Ann Liebert, Inc
Language: English
Date published: 07/2009
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047887902771

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