Analysis of HIV tropism in Ugandan infants

Jessica D Church; Wei Huang; Anthony Mwatha; Philippa Musoke; J. Brooks Jackson; Danstan Bagenda; Saad B Omer; Deborah Donnell; Clemensia Nakabiito; Chineta Eure; Laura A Guay; Allan Taylor; Paul M Bakaki; Flavia Matovu; Michelle McConnell; Mary Glenn Fowler; Susan H Eshleman

doi:10.2174/157016210793499187

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Analysis of HIV tropism in Ugandan infants

Journal article

Open access

Peer reviewed

Analysis of HIV tropism in Ugandan infants

Jessica D Church, Wei Huang, Anthony Mwatha, Philippa Musoke, J. Brooks Jackson, Danstan Bagenda, Saad B Omer, Deborah Donnell, Clemensia Nakabiito, Chineta Eure, …

Current HIV research, Vol.8(7), pp.498-503

10/01/2010

DOI: 10.2174/157016210793499187

PMCID: PMC3075545

PMID: 21073438

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https://www.ncbi.nlm.nih.gov/pmc/articles/3075545View

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Abstract

HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV-infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6–8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6–12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6–8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

HIV-1

transmission

survival

tropism

CXCR4

CCR5

infant

Details

Title: Subtitle: Analysis of HIV tropism in Ugandan infants
Creators: Jessica D Church - Johns Hopkins Univ. School of Medicine, Baltimore, MD, USA
Wei Huang - Monogram Biosciences, South San Francisco, CA, USA
Anthony Mwatha - Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Philippa Musoke - Makerere University School of Medicine, Kampala, Uganda
J. Brooks Jackson - Johns Hopkins Univ. School of Medicine, Baltimore, MD, USA
Danstan Bagenda - Makerere University School of Public Health, Kampala, Uganda
Saad B Omer - Johns Hopkins Univ. School of Public Health, Baltimore, MD, USA
Deborah Donnell - Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Clemensia Nakabiito - Makerere University School of Medicine, Kampala, Uganda
Chineta Eure - Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Laura A Guay - Johns Hopkins Univ. School of Medicine, Baltimore, MD, USA
Allan Taylor - Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Paul M Bakaki - Makerere University – Johns Hopkins University (MUJHU) Research Collaboration, Kampala, Uganda
Flavia Matovu - Makerere University – Johns Hopkins University (MUJHU) Research Collaboration, Kampala, Uganda
Michelle McConnell - Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Mary Glenn Fowler - Johns Hopkins Univ. School of Medicine, Baltimore, MD, USA
Susan H Eshleman - Johns Hopkins Univ. School of Medicine, Baltimore, MD, USA
Resource Type: Journal article
Publication Details: Current HIV research, Vol.8(7), pp.498-503
DOI: 10.2174/157016210793499187
PMID: 21073438
PMCID: PMC3075545
NLM abbreviation: Curr HIV Res
ISSN: 1570-162X
eISSN: 1873-4251
Language: English
Date published: 10/01/2010
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047897202771

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