Journal article
Analysis of audiometric notch as a noise-induced hearing loss phenotype in US youth: data from the National Health And Nutrition Examination Survey, 2005-2010
International journal of audiology, Vol.56(6), pp.392-399
06/03/2017
DOI: 10.1080/14992027.2017.1278799
PMID: 28635495
Abstract
Objective: Bilateral audiometric notch (BN) at 4000-6000 Hz was identified as a noise-induced hearing loss (NIHL) phenotype for genetic association analysis in college-aged musicians. This study analysed BN in a sample of US youth. Design: Prevalence of the BN within the study sample was determined and logistic-regression analyses were performed to identify audiologic and other demographic factors associated with BN. Computer-simulated "flat" audiograms were used to estimate potential influence of false-positive rates in estimating the prevalence of the BN. Study sample: 2348 participants (12-19 years) following the inclusion criteria were selected from the National Health and Nutrition Examination Survey data (2005-2010). Results: The prevalence of BN was 16.6%. Almost 55.6% of the participants showed notch in at least one ear. Noise exposure, gender, ethnicity and age showed significant relationship with the BN. Computer simulation revealed that 5.5% of simulated participants with "flat" audiograms showed BN. Conclusion: Association of noise exposure with BN suggests that it is a useful NIHL phenotype for genetic association analyses. However, further research is necessary to reduce false-positive rates in notch identification.
Details
- Title: Subtitle
- Analysis of audiometric notch as a noise-induced hearing loss phenotype in US youth: data from the National Health And Nutrition Examination Survey, 2005-2010
- Creators
- Ishan S. Bhatt - Northern Arizona UniversityO'neil Guthrie - Northern Arizona University
- Resource Type
- Journal article
- Publication Details
- International journal of audiology, Vol.56(6), pp.392-399
- Publisher
- Taylor & Francis
- DOI
- 10.1080/14992027.2017.1278799
- PMID
- 28635495
- ISSN
- 1499-2027
- eISSN
- 1708-8186
- Grant note
- Northern Arizona University
- Language
- English
- Date published
- 06/03/2017
- Academic Unit
- Communication Sciences and Disorders
- Record Identifier
- 9984258850602771
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