Journal article
Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (pediatric AIDS Clinical Trials Group 377)
The Journal of infectious diseases, Vol.183(12), pp.1732-1738
2001
DOI: 10.1086/320728
PMID: 11372025
Abstract
In Pediatric AIDS Clinical Trials Group 377, antiretroviral therapy-experienced children were randomized to 4 treatment arms that included different combinations of stavudine, lamivudine (3TC), nevirapine (Nvp), nelfinavir (Nfv), and ritonavir (Rtv). Previous treatment with zidovudine (Zdv), didanosine (ddI), or zalcitabine (ddC) was acceptable. Drug resistance (R) mutations were assessed before study treatment (baseline) and at virologic failure. ZdvR, ddIR, and ddCRmutations were detected frequently at baseline but were not associated with virologic failure. Children with drug resistance mutations at baseline had greater reductions in virus load over time than did children who did not. NvpRand 3TCRmutations were detected frequently at virologic failure, and NvpRmutations were more common among children receiving 3-drug versus 4-drug Nvp-containing regimens. Children who were maintained on their study regimen after virologic failure accumulated additional NvpRand 3TCRmutations plus RtvRand NfvRmutations. However, RtvRand NfvRmutations were detected at unexpectedly low rates.
Details
- Title: Subtitle
- Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (pediatric AIDS Clinical Trials Group 377)
- Creators
- Susan H ESHLEMAN - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesPaul KROGSTAD - Department of Pediatrics, University of California, Los Angeles School of Medicine, Los Angeles, United StatesSharon NACHMAN - Department of Pediatrics, Medical University of South Carolina, Charleston, United StatesPaul PALUMBO - Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, United StatesJ. Brooks JACKSON - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesYou-Gan WANG - Statistical Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts, United StatesSophia LEE - Statistical Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts, United StatesLee-Jen WEI - Statistical Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts, United StatesShawn CUNNINGHAM - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesMichael WANTMAN - Statistical Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts, United StatesAndrew WIZNIA - Department of Pediatrics. Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, Stony Brook, United StatesGeorge JOHNSON - Department of Pediatrics, State University of New York, Stony Brook, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.183(12), pp.1732-1738
- Publisher
- University of Chicago Press; Chicago, IL
- DOI
- 10.1086/320728
- PMID
- 11372025
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 2001
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047612702771
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