Journal article
Analysis of monophasic and biphasic electrical stimulation of nerve
IEEE transactions on biomedical engineering, Vol.48(10), pp.1065-1070
10/01/2001
DOI: 10.1109/10.951508
PMID: 11585029
Abstract
In an earlier study, biphasic and monphasic electrical stimulation of the auditory nerve was performed in cats with a cochlear implant. Single-unit recordings demonstrated that spikes resulting from monophasic and biphasic stimuli have different thresholds and latencies. Monophasic thresholds are lower and latencies are shorter under cathodic stimulation. Results from stochastic simulations of a biophysical model of electrical stimulation are similar. A simple analysis of a linear, "integrate to threshold" membrane model accounts for the threshold and latency differences observed experimentally and computationally. Since biphasic stimuli are used extensively in functional electrical stimulation, this analysis greatly simplifies the biophysical interpretation of responses to clinically relevant stimuli by relating them to the responses obtained with monophasic stimuli.
Details
- Title: Subtitle
- Analysis of monophasic and biphasic electrical stimulation of nerve
- Creators
- Jay T Rubinstein - University of IowaCharles A Miller - University of IowaHiroyuki Mino - University of IowaPaul J Abbas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on biomedical engineering, Vol.48(10), pp.1065-1070
- Publisher
- Institute of Electrical and Electronics Engineers
- DOI
- 10.1109/10.951508
- PMID
- 11585029
- ISSN
- 0018-9294
- eISSN
- 1558-2531
- Language
- English
- Date published
- 10/01/2001
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984383908302771
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