Analysis of shared heritability in common disorders of the brain

Brain Storm Consortium; Verneri Anttila; Brendan Bulik-Sullivan; Hilary K Finucane; Raymond K Walters; Jose Bras; Laramie Duncan; Valentina Escott-Price; Guido J Falcone; Padhraig Gormley; Rainer Malik; Nikolaos A Patsopoulos; Stephan Ripke; James Walters; Zhi Wei; Dongmei Yu; Phil H Lee; Patrick Turley; Gerome Breen; Claire Churchhouse; Cynthia M Bulik; Mark Daly; Martin Dichgans; Bru Cormand Rifà; Raquel Rabionet Janssen; International Genomics of Alzheimer’s Project (IGAP); International Headache Genetics Consortium (IHGC)

doi:10.1126/science.aap8757

Back

Analysis of shared heritability in common disorders of the brain

Journal article

Open access

Peer reviewed

Analysis of shared heritability in common disorders of the brain

Brain Storm Consortium, Verneri Anttila, Brendan Bulik-Sullivan, Hilary K Finucane, Raymond K Walters, Jose Bras, Laramie Duncan, Valentina Escott-Price, Guido J Falcone, Padhraig Gormley, …

Science, Vol.360(6395), eaap8757

06/22/2018

DOI: 10.1126/science.aap8757

PMCID: PMC6097237

PMID: 29930110

Files and links (1)

url

https://doi.org/10.1126/science.aap8757View

Published (Version of record) Open Access

Abstract

Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multiple genome-wide association studies drawn from more than 200,000 patients for 25 brain-associated disorders and 17 phenotypes. Broadly, it appears that psychiatric and neurologic disorders share relatively little common genetic risk. However, different and independent pathways can result in similar clinical manifestations (e.g., psychosis, which occurs in both schizophrenia and Alzheimer's disease). Schizophrenia correlated with many psychiatric disorders, whereas the immunopathological affliction Crohn's disease did not, and posttraumatic stress syndrome was also largely independent of underlying traits. Essentially, the earlier the onset of a disorder, the more inheritable it appeared to be.

Brain diseases

Malalties cerebrals

Details

Title: Subtitle: Analysis of shared heritability in common disorders of the brain
Creators: Brain Storm Consortium
Verneri Anttila - Broad Institute
Brendan Bulik-Sullivan - Broad Institute
Hilary K Finucane
Raymond K Walters - Broad Institute
Jose Bras - University College London
Laramie Duncan
Valentina Escott-Price - Cardiff University
Guido J Falcone - Harvard University
Padhraig Gormley
Rainer Malik - Ludwig-Maximilians-Universität München
Nikolaos A Patsopoulos - Broad Institute
Stephan Ripke
James Walters
Zhi Wei - New Jersey Institute of Technology
Dongmei Yu - Broad Institute
Phil H Lee - Broad Institute
Patrick Turley - Broad Institute
Gerome Breen
Claire Churchhouse
Cynthia M Bulik
Mark Daly
Martin Dichgans
Bru Cormand Rifà
Raquel Rabionet Janssen
International Genomics of Alzheimer’s Project (IGAP)
International Headache Genetics Consortium (IHGC)
Contributors: Thomas H Wassink (Contributor) - University of Iowa, Psychiatry
Resource Type: Journal article
Publication Details: Science, Vol.360(6395), eaap8757
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aap8757
PMID: 29930110
PMCID: PMC6097237
ISSN: 0036-8075
eISSN: 1095-9203
Grant note: DOI: 10.13039/100000025, name: National Institute of Mental Health, award: 1R01MH10764901; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: 5U01MH09443203; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R00MH101367; DOI: 10.13039/501100004359, name: Vetenskapsrådet, award: 538-2013-8864; DOI: 10.13039/501100000272, name: UK National Institute of Health Research, award: Biomedical Research Centre at the Maudsley; name: NIHR UCLH Biomedical research centre, award: BRC; name: Parkinsons UK, award: Exome sequencing in PD; name: MRC-JPND, award: 515066
Language: English
Date published: 06/22/2018
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984281754102771

Metrics

23 Record Views

1242 Times Cited - Web of Science

See more details