Journal article
Analysis of vagally induced sinus arrhythmias
Journal of theoretical biology, Vol.159(4), pp.507-511
12/21/1992
DOI: 10.1016/S0022-5193(05)80694-0
PMID: 1296102
Abstract
Vagal stimulation at precise times in successive cardiac cycles can elicit sinus arrhythmias. Two mechanisms have been identified that can, but do not necessarily, cause these vagally induced sinus arrhythmias. First, changes in cycle length elicited by a given concentration of acetylcholine (ACh) depend on the phase of the pacemaker cell action potential when the ACh binds to muscarinic receptors. Second, acetylcholinesterase degrades ACh rapidly enough for the mean concentration of ACh per cardiac cycle to vary from cycle to cycle. We used a mathematical model of the underlying cellular physiology, to examine whether these mechanisms are responsible for arrhythmogenesis. Computer simulation showed that both mechanisms contribute to the vagally induced sinus arrhythmias.
Details
- Title: Subtitle
- Analysis of vagally induced sinus arrhythmias
- Creators
- Franklin Dexter - Department of Anesthesia, University of Iowa Hospitals, Iowa City 52242Tianen YangMatthew N Levy
- Resource Type
- Journal article
- Publication Details
- Journal of theoretical biology, Vol.159(4), pp.507-511
- Publisher
- England
- DOI
- 10.1016/S0022-5193(05)80694-0
- PMID
- 1296102
- ISSN
- 0022-5193
- eISSN
- 1095-8541
- Grant note
- HL 10951 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/21/1992
- Academic Unit
- Health Management and Policy; Anesthesia
- Record Identifier
- 9983806371002771
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