Journal article
Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia
The Journal of pathology, Vol.221(3), pp.242-247
07/2010
DOI: 10.1002/path.2714
PMCID: PMC3118561
PMID: 20527018
Abstract
Mouse models may provide an important tool for basic and applied research on human diseases. An ideal tumour model should replicate the phenotypic and molecular characteristics of human malignancy as well as the typical physiological effects and dissemination patterns. The histopathological and molecular genetic characterization of anaplastic plasmacytoma (APCT) in strain NSF.V(+) mice provides an example to achieve this goal for a specific lymphoma subtype. Firstly, it demonstrates that, like plasma-cell neoplasms in humans, those in mice occur as distinct subtypes. Secondly, it shows that mouse APCT exhibits striking parallels to possible human tumour counterparts for which good mouse models of de novo tumour development are sorely needed: IgM(+) multiple myeloma and Waldenström's macroglobulinaemia. Thirdly, it strongly suggests that insertional somatic mutagenesis, by either a murine leukaemia virus or an oncogenic transposon, would be an effective experimental approach to accelerating malignant transformation of mature B cells and plasma cells in mice and, thereby, tagging and uncovering cancer driver genes that may be of great relevance for the tumour initiation and progression in lymphoma.
Details
- Title: Subtitle
- Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia
- Creators
- Daphne de Jong - Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. d.d.jong@nki.nlSiegfried Janz
- Resource Type
- Journal article
- Publication Details
- The Journal of pathology, Vol.221(3), pp.242-247
- DOI
- 10.1002/path.2714
- PMID
- 20527018
- PMCID
- PMC3118561
- ISSN
- 0022-3417
- eISSN
- 1096-9896
- Grant note
- R01 CA151354-01 / NCI NIH HHS R01 CA151354 / NCI NIH HHS
- Language
- English
- Date published
- 07/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984083830602771
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