Journal article
Anatomical and physiological factors contributing to chronic muscle pain
Current topics in behavioral neurosciences, Vol.20, pp.327-348
2014
DOI: 10.1007/7854_2014_294
PMCID: PMC4294469
PMID: 24633937
Abstract
Chronic muscle pain remains a significant source of suffering and disability despite the adoption of pharmacologic and physical therapies. Muscle pain is mediated by free nerve endings distributed through the muscle along arteries. These nerves project to the superficial dorsal horn and are transmitted primarily through the spinothalamic tract to several cortical and subcortical structures, some of which are more active during the processing of muscle pain than other painful conditions. Mechanical forces, ischemia, and inflammation are the primary stimuli for muscle pain, which is reflected in the array of peripheral receptors contributing to muscle pain-ASIC, P2X, and TRP channels. Sensitization of peripheral receptors and of central pain processing structures are both critical for the development and maintenance of chronic muscle pain. Further, variations in peripheral receptors and central structures contribute to the significantly greater prevalence of chronic muscle pain in females.
Details
- Title: Subtitle
- Anatomical and physiological factors contributing to chronic muscle pain
- Creators
- Nicholas S Gregory - Neuroscience Graduate Program, University of Iowa, 3144 Med Labs, Iowa City, IA, 52246, USA, Nicholas-s-gregory@uiowa.eduKathleen A Sluka
- Resource Type
- Journal article
- Publication Details
- Current topics in behavioral neurosciences, Vol.20, pp.327-348
- Publisher
- Germany
- DOI
- 10.1007/7854_2014_294
- PMID
- 24633937
- PMCID
- PMC4294469
- eISBN
- 3662450941; 9783662450949
- ISSN
- 1866-3370
- eISSN
- 1866-3389
- Grant note
- R01 AR061371 / NIAMS NIH HHS\nR01 AR052316 / NIAMS NIH HHS\nR01 AR053509 / NIAMS NIH HHS\nT32 NS045549 / NINDS NIH HHS\nT32 GM007337 / NIGMS NIH HHS
- Language
- English
- Date published
- 2014
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984071973702771
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