Anatomical and physiological measures of auditory system in mice with peripheral myelin deficiency

Renzhi Zhou; Jose G Assouline; Paul J Abbas; Albee Messing; Bruce J Gantz

doi:10.1016/0378-5955(95)00104-C

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Anatomical and physiological measures of auditory system in mice with peripheral myelin deficiency

Journal article

Peer reviewed

Anatomical and physiological measures of auditory system in mice with peripheral myelin deficiency

Renzhi Zhou, Jose G Assouline, Paul J Abbas, Albee Messing and Bruce J Gantz

Hearing research, Vol.88(1), pp.87-97

1995

DOI: 10.1016/0378-5955(95)00104-C

PMID: 8576008

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Abstract

Animal models with genetic abnormalities have been increasingly used in auditory research. Both Tr J mice and P o-DT-A mice are animals with peripheral myelin deficiency. In Tr J mice, the defect is due to a mutated PMP-22 gene. In P o-DT-A mice, the defect is produced by a transgene using the rat P o promotor to direct the expression of gene encoding for the bacterial diphtherial toxin A chain (DT-A). This study evaluates the auditory system both physiologically and histologically in these two strains of mice. Histological examination revealed that there was myelin deficiency of the auditory nerve fibers, accompanied by a loss of dendrites and a loss of spiral ganglion cell bodies in both strains of mice. In general, histological deficits in Tr J mice were greater than those in P o-DT-A mice. There was a strong correlation between the degree of myelin deficiency and the survival of spiral ganglion neurons. ABR measurements exhibited differences in threshold, latency and slope of the ABR growth function between myelin-deficient mice and their respective controls. These results suggest that the integrity of the myelin in the auditory nerve is important both for neural survival and for normal electrophysiological function of spiral ganglion neurons.

Myelin deficiency

Cochlea

Transgenic mouse

Auditory brainstem response

Myelin

Schwann cell

Details

Title: Subtitle: Anatomical and physiological measures of auditory system in mice with peripheral myelin deficiency
Creators: Renzhi Zhou - Department of Speech Pathology and Audiology, University of Iowa, Iowa City, IA, USA
Jose G Assouline - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, IA, USA
Paul J Abbas - Department of Speech Pathology and Audiology, University of Iowa, Iowa City, IA, USA
Albee Messing - Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
Bruce J Gantz - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Hearing research, Vol.88(1), pp.87-97
DOI: 10.1016/0378-5955(95)00104-C
PMID: 8576008
NLM abbreviation: Hear Res
ISSN: 0378-5955
eISSN: 1878-5891
Publisher: Elsevier B.V
Language: English
Date published: 1995
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Communication Sciences and Disorders; Iowa Neuroscience Institute; Urology; Neurosurgery; Otolaryngology
Record Identifier: 9984070597302771

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