Journal article
Anatomical feasibility of performing intercostal and ilioinguinal nerve to pelvic nerve transfer: a possible technique to restore lower urinary tract innervation Laboratory investigation
Journal of neurosurgery. Spine, Vol.17(4), pp.357-362
10/01/2012
DOI: 10.3171/2012.7.SPINE12214
PMID: 22881037
Abstract
Object. Nerve transfers are effective for restoring control to paralyzed somatic muscle groups and, recently, even to denervated detrusor muscle in a canine model. A pilot project was performed in cadavers to examine the feasibility of transferring somatic nerves to vesical branches of the pelvic nerve as a method for potentially restoring innervation to control the detrusor muscle in humans.
Methods. Eleven cadavers were dissected bilaterally to expose intercostal, ilioinguinal, and iliohypogastric nerves, along with vesical branches of the pelvic nerve. Ease of access and ability to transfer the former 3 nerves to the pelvic vesical nerves were assessed, as were nerve cross-sectional areas.
Results. The pelvic vesical nerves were accessed at the base of the bladder, inferior to the ureter and accompanied by inferior vesical vessels. The T-11 and T-12 intercostal nerves were too short for transfer to the pelvic vesical nerves without grafting. Ilioinguinal and iliohypogastric nerves (L-1 origin) were identified retroperitoneally and, with full dissection, were easily transferred to the pelvic vesical nerves intraabdominally. The mean cross-sectional area of the dominant pelvic vesical branch was 2.60 +/- 0.169 mm(2); ilioinguinal and iliohypogastric branches at the suggested transection site were 2.38 +/- 0.32 mm(2) (the means are expressed +/- SEM).
Conclusions. Use of the ilioinguinal or iliohypogastric nerves for heterotopic transfer to pelvic vesical nerves is surgically feasible, based on anatomical location and cross-sectional areas. (http://thejns.org/doi/abs/10.3171/2012.7.SPINE12214)
Details
- Title: Subtitle
- Anatomical feasibility of performing intercostal and ilioinguinal nerve to pelvic nerve transfer: a possible technique to restore lower urinary tract innervation Laboratory investigation
- Creators
- Justin M. Brown - University of California San DiegoMary F. Barbe - Temple UniversityMichael E. Albo - University of California San Diego Medical CenterH. Henry Lai - Washington University in St. LouisMichael R. Ruggieri - Shriners Hospitals for Children - Philadelphia
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery. Spine, Vol.17(4), pp.357-362
- DOI
- 10.3171/2012.7.SPINE12214
- PMID
- 22881037
- NLM abbreviation
- J Neurosurg Spine
- ISSN
- 1547-5654
- eISSN
- 1547-5646
- Publisher
- Amer Assoc Neurological Surgeons
- Number of pages
- 6
- Grant note
- 1R01NS070267 / NIH-NINDS (National Institute of Neurological Disorders and Stroke) R01NS070267 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 10/01/2012
- Academic Unit
- Urology
- Record Identifier
- 9985244653502771
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