Andes Virus Exposure and Nosocomial Transmission Events to Healthcare Personnel: A Systematic Review

Loukas Kakoullis; Erin Rebecca Carr; Jhony Baissary; Stephanie Friree Ford; Shinya Hasegawa; Jacob E Lazarus; Karen Brust; Erica S Shenoy

doi:10.1093/cid/ciag394

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Andes Virus Exposure and Nosocomial Transmission Events to Healthcare Personnel: A Systematic Review

Journal article

Peer reviewed

Andes Virus Exposure and Nosocomial Transmission Events to Healthcare Personnel: A Systematic Review

Loukas Kakoullis, Erin Rebecca Carr, Jhony Baissary, Stephanie Friree Ford, Shinya Hasegawa, Jacob E Lazarus, Karen Brust and Erica S Shenoy

Clinical infectious diseases

06/29/2026

DOI: 10.1093/cid/ciag394

PMID: 42372085

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Abstract

Andes virus (ANDV) is a high-consequence infectious disease with substantial mortality. On May 2, 2026, the World Health Organization reported a multinational ANDV outbreak, raising questions regarding risk of transmission to healthcare personnel (HCP). We performed a systematic review per PRISMA guidelines (PROSPERO:CRD420261283806) for studies describing healthcare-associated ANDV exposure or transmission events to HCP. Eight studies reporting on 7 events were included, describing a total of 17 healthcare-associated cases. Overall, 207 individuals were exposed, including 118 HCP, resulting in 8 infections and 4 deaths among HCP. Studies describing HCP infections reported none or inadequate personal protective equipment (PPE) use. Transmission of ANDV to HCP has been reported in the setting of delayed implementation of transmission-based precautions or breaches in infection control practice. Limitations in published exposure events highlight the need for standardized reporting of exposure events and outcomes as well as infection prevention measures implemented.

Andes virus

Hantavirus

Hospital Epidemiology

Infection Control

Details

Title: Subtitle: Andes Virus Exposure and Nosocomial Transmission Events to Healthcare Personnel: A Systematic Review
Creators: Loukas Kakoullis - Harvard University
Erin Rebecca Carr - Brigham and Women's Hospital
Jhony Baissary - Mount Auburn Hospital
Stephanie Friree Ford - Massachusetts General Hospital
Shinya Hasegawa - University of Iowa
Jacob E Lazarus - Harvard University
Karen Brust - University of Iowa
Erica S Shenoy - Harvard University
Resource Type: Journal article
Publication Details: Clinical infectious diseases
DOI: 10.1093/cid/ciag394
PMID: 42372085
ISSN: 1537-6591
eISSN: 1537-6591
Publisher: Oxford University Press
Language: English
Electronic publication date: 06/29/2026
Academic Unit: Internal Medicine
Record Identifier: 9985178660702771

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