Journal article
Anencephaly and spina bifida among Hispanics: Maternal, sociodemographic, and acculturation factors in the National Birth Defects Prevention Study
Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(6), pp.637-646
07/2009
DOI: 10.1002/bdra.20582
PMID: 19334286
Abstract
BACKGROUND: We used data from the multisite National Birth Defects Prevention Study for expected delivery dates from October 1997 through 2003, to determine whether the increased risk in anencephaly and spina bifida (neural tube defects (NTDs)) in Hispanics was explained by selected sociodemographic, acculturation, and other maternal characteristics. METHODS: For each type of defect, we examined the association with selected maternal characteristics stratified by race/ethnicity and the association with Hispanic parents' acculturation level, relative to non-Hispanic whites. We used logistic regression and calculated crude odds ratios (ORs) and their 95% confidence intervals (CIs). RESULTS: Hispanic mothers who reported the highest level of income were 80% less likely to deliver babies with spina bifida. In addition, highly educated Hispanic and white mothers had 76 and 35% lower risk, respectively. Other factors showing differing effects for spina bifida in Hispanics included maternal age, parity, and gestational diabetes. For spina bifida there was no significant elevated risk for U.S.–born Hispanics, relative to whites, but for anencephaly, corresponding ORs ranged from 1.9 to 2.3. The highest risk for spina bifida was observed for recent Hispanic immigrant parents from Mexico or Central America residing in the United States <5 years (OR = 3.28, 95% CI = 1.46–7.37). CONCLUSIONS: Less acculturated Hispanic parents seemed to be at highest risk of NTDs. For anencephaly, U.S.–born and English-speaking Hispanic parents were also at increased risk. Finally, from an etiologic standpoint, spina bifida and anencephaly appeared to be etiologically heterogeneous from these analyses.
Details
- Title: Subtitle
- Anencephaly and spina bifida among Hispanics: Maternal, sociodemographic, and acculturation factors in the National Birth Defects Prevention Study
- Creators
- Mark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasTunu A Ramadhani - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasGary M Shaw - March of Dimes California Research Division, Oakland, CaliforniaSuzan L Carmichael - March of Dimes California Research Division, Oakland, CaliforniaD. Kim Waller - School of Public Health, Houston Health Science Center, University of Texas, Houston, TexasBridget S Mosley - Department of Pediatrics in the College of Medicine, University of Arkansas Children's Hospital Research Institute, Little Rock, ArkansasMarjorie H Royle - New Jersey Department of Health and Senior Services, Trenton, New JerseyRichard S Olney - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(6), pp.637-646
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/bdra.20582
- PMID
- 19334286
- ISSN
- 1542-0752
- eISSN
- 1096-9926
- Number of pages
- 10
- Language
- English
- Date published
- 07/2009
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214660902771
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