Anesthesia and the developing brain

John Aker; Robert I Block; Chuck Biddle

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Journal article

Peer reviewed

Anesthesia and the developing brain

John Aker, Robert I Block and Chuck Biddle

AANA journal, Vol.83(2), pp.139-147

04/2015

PMID: 26016173

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Abstract

Despite the profound evolution in the safety and efficacy of neonatal and pediatric anesthesia, questions remain concerning the long-term neurotoxic and neurocognitive effects of the drugs used in anesthetic care. A variety of prospective animal models and retrospective human studies exist that inconsistently demonstrate a detrimental effect of early life exposure to anesthetic drugs and subsequent learning performance. Limitations associated with both non-human and human observational studies are critiqued. Research currently underway is briefly described. A framework for discussing the relevant issues with concerned parents is presented.

Animals, Newborn

Neurotoxins

Prospective Studies

Apoptosis - drug effects

Humans

Anesthetics, General - adverse effects

Brain - growth & development

Cognition - drug effects

Brain - drug effects

Animals

Nurse Anesthetists - education

Retrospective Studies

Education, Nursing, Continuing

Neurons - drug effects

Child

Infant, Newborn

Disease Models, Animal

Details

Title: Subtitle: Anesthesia and the developing brain
Creators: John Aker
Robert I Block
Chuck Biddle
Resource Type: Journal article
Publication Details: AANA journal, Vol.83(2), pp.139-147
Publisher: United States
PMID: 26016173
ISSN: 0094-6354
eISSN: 2162-5239
Language: English
Date published: 04/2015
Academic Unit: Iowa Neuroscience Institute; Anesthesia
Record Identifier: 9984007175902771

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