Journal article
Anesthetic Management of Children and Adolescents With Giant Axonal Neuropathy: A Large Case Series
A & A case reports, Vol.15(10), pp.e01539-e01539
10/01/2021
DOI: 10.1213/XAA.0000000000001539
PMID: 34695041
Abstract
Giant axonal neuropathy (GAN) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the GAN gene, which encodes for gigaxonin, a protein involved in intermediate filament processing in neural cells and fibroblasts. We report on 14 GAN patients who underwent 77 anesthetics during the conduct of an intrathecal gene transfer clinical trial from April 2015 to August 2020. We observed only a few nonsignificant perianesthetic complications. Our data expand the knowledge regarding safety of anesthesia for patients with this rare and potentially fatal disease and highlights the tolerability of shorter procedural sedation and anesthesia.
Details
- Title: Subtitle
- Anesthetic Management of Children and Adolescents With Giant Axonal Neuropathy: A Large Case Series
- Creators
- Muhammad Yousef - National Institutes of Health Clinical CenterDiana Bharucha-Goebel - National Institute of Neurological Disorders and StrokeDimah Saade - National Institute of Neurological Disorders and StrokeGilberto Averion - National Institute of Neurological Disorders and StrokeCarsten G. Bonnemann - National Institute of Neurological Disorders and StrokeZenaide M. N. Quezado - National Institutes of Health Clinical Center
- Resource Type
- Journal article
- Publication Details
- A & A case reports, Vol.15(10), pp.e01539-e01539
- DOI
- 10.1213/XAA.0000000000001539
- PMID
- 34695041
- NLM abbreviation
- A A Case Rep
- ISSN
- 2325-7237
- eISSN
- 2325-7237
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- Intramural Research Program of the National Institutes of Health Clinical Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984354040702771
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