Journal article
Aneurysm Wall Enhancement Is Associated With Decreased Intrasaccular IL-10 and Morphological Features of Instability
Neurosurgery, Vol.89(4), pp.664-671
10/01/2021
DOI: 10.1093/neuros/nyab249
PMCID: PMC8578742
PMID: 34245147
Abstract
BACKGROUND: High-resolution vessel wall imaging plays an increasingly important role in assessing the risk of aneurysm rupture.
OBJECTIVE: To introduce an approach toward the validation of the wall enhancement as a direct surrogate parameter for aneurysm stability.
METHODS: A total of 19 patients harboring 22 incidental intracranial aneurysms were enrolled in this study. The aneurysms were dichotomized according to their aneurysmto-pituitary stalk contrast ratio using a cutoff value of 0.5 (nonenhancing < 0.5; enhancing >= 0.5). We evaluated the association of aneurysm wall enhancement with morphological characteristics, hemodynamic features, and inflammatory chemokines directly measured inside the aneurysm.
RESULTS: Differences in plasma concentration of chemokines and inflammatory molecules, morphological, and hemodynamic parameters were analyzed using the Welch test or Mann-Whitney U test. The concentration Delta IL-10 in the lumen of intracranial aneurysms with low wall enhancement was significantly increased compared to aneurysms with strong aneurysm wall enhancement (P =.014). The analysis of morphological and hemodynamic parameters showed significantly increased values for aneurysm volume (P=.03), aneurysmarea (P=.044), maximal diameter (P=.049), and nonsphericity index (P=.021) for intracranial aneurysms with strong aneurysm wall enhancement. None of the hemodynamic parameters reached statistical significance; however, the total viscous shear force computed over the region of low wall shear stress showed a strong tendency toward significance (P =.053).
CONCLUSION: Aneurysmal wall enhancement shows strong associations with decreased intrasaccular IL-10 and established morphological indicators of aneurysm instability.
Details
- Title: Subtitle
- Aneurysm Wall Enhancement Is Associated With Decreased Intrasaccular IL-10 and Morphological Features of Instability
- Creators
- Vanessa M. Swiatek - Otto von Guericke Univ, Dept Neurosurg, Magdeburg, Saxony Anhalt, GermanyBelal Neyazi - Otto von Guericke Univ, Dept Neurosurg, Magdeburg, Saxony Anhalt, GermanyJorge A. Roa - Univ Iowa Hosp & Clin, Dept Neurosurg, 200 Hawkins Dr, Iowa City, IA 52242 USAMario Zanaty - University of IowaEdgar A. Samaniego - University of IowaDaizo Ishii - University of IowaYongjun Lu - University of IowaI. Erol Sandalcioglu - Otto von Guericke Univ, Dept Neurosurg, Magdeburg, Saxony Anhalt, GermanySylvia Saalfeld - Univ Magdeburg, Dept Simulat & Graph, Magdeburg, Saxony Anhalt, GermanyPhilipp Berg - Res Campus STIMULATE, Magdeburg, Saxony Anhalt, GermanyDavid M. Hasan - Univ Iowa Hosp & Clin, Dept Neurosurg, 200 Hawkins Dr, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Neurosurgery, Vol.89(4), pp.664-671
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1093/neuros/nyab249
- PMID
- 34245147
- PMCID
- PMC8578742
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Number of pages
- 8
- Grant note
- NS107293 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 13GW0473A / Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) SA 3461/2-1; BE 6230/2-1 / German Research Foundation; German Research Foundation (DFG) 2019 Bee Foundation Aneurysm Research Grant Society of Vascular and Interventional Neurology Grant
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Critical Care; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984419130802771
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